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General Information
Symbol
Dmel\Nop60BGL00555
Species
D. melanogaster
Name
FlyBase ID
FBal0266255
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a short inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Third instar larvae (at 96 and 120h after egg deposition) with expression of Nop60BGL00555 driven by Scer\GAL4bi.PU show strong tissue disorganization and increased cell death along the A/P border in wing discs; there is evidence for apoptosis-induced proliferation (significant increase in proliferating cells). Epithelial-mesenchymal transition is induced in the peripodial membrane (cell fate changes) with silencing of Nop60BGL00555 driven by Scer\GAL4bi.PU in third instar larval wing discs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Suppressed by
Additional Comments
Genetic Interactions
Statement
Reference

wgSH1281 suppresses apoptosis-induced increases in proliferative activity in Scer\GAL4bi.PU>Nop60BGL00555 wing discs.

Xenogenetic Interactions
Statement
Reference

Co-expression of BacA\p35Scer\UAS.cHa enhances wing disc phenotypes, with 'undead' cells secreting high levels of wg along the A/P margin, in Scer\GAL4bi.PU>Nop60BGL00555 third instar larval wing discs; co-expression of BacA\p35Scer\UAS.cHa also further increases mitotic activity.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Nop60BGL00555
Name Synonyms
Secondary FlyBase IDs
    References (2)