FlyBase Allele Report: Dmel\Kdm5[GL00612]

General Information

Symbol

Dmel\Kdm5^GL00612

Species

D. melanogaster

Name

FlyBase ID

FBal0266311

Feature type

allele

Associated gene

Dmel\Kdm5

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00612}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00612}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00612

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number, with Scer\GAL4^nanos.PU

(Tarayrah et al., 2015)

decreased occurrence of cell division, with Scer\GAL4^nanos.PU

(Tarayrah et al., 2015)

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Torres-Campana et al., 2022)

female sterile, with Scer\GAL4^{VP16.nanos.UTR}

(Zhaunova et al., 2016)

Phenotype Manifest In

germinal proliferation center hub, with Scer\GAL4^nanos.PU

(Tarayrah et al., 2015)

karyosome | adult stage, with Scer\GAL4^{VP16.nanos.UTR}

(Zhaunova et al., 2016)

male germline stem cell, with Scer\GAL4^nanos.PU

(Tarayrah et al., 2015)

oocyte | adult stage, with Scer\GAL4^{VP16.nanos.UTR}

(Zhaunova et al., 2016)

Detailed Description

Statement

Reference

Expression of lid^GL00612 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} in female germlines results in sterility and abnormal morphology of the karyosome in most oocytes.

(Zhaunova et al., 2016)

Scer\GAL4^nos.PU driven knockdown of lid^GL00612 leads to a significant decrease in germline stem cell (GSC) number, a significant increase in average hub area, and a decrease in mitotic activity of GSCs in the testes compared to wild type.

(Tarayrah et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Kdm5^GL00612, Scer\GAL4^nanos.PU has decreased cell number phenotype, suppressible by Stat92E^UAS.cPa, Scer\GAL4^nanos.PU

(Tarayrah et al., 2015)

Kdm5^GL00612, Scer\GAL4^nanos.PU has decreased cell number phenotype, suppressible by Ptp61F^HMS00421, Scer\GAL4^nanos.PU

(Tarayrah et al., 2015)

Phenotype Manifest In

Suppressed by

Statement

Reference

Kdm5^GL00612, Scer\GAL4^nanos.PU has male germline stem cell phenotype, suppressible by Stat92E^UAS.cPa, Scer\GAL4^nanos.PU

(Tarayrah et al., 2015)

Kdm5^GL00612, Scer\GAL4^nanos.PU has male germline stem cell phenotype, suppressible by Ptp61F^HMS00421, Scer\GAL4^nanos.PU

(Tarayrah et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Stat92E^Scer\UAS.cPa suppresses the germline stem cell loss seen in testes with lid^GL00612 driven by Scer\GAL4^nos.PU.

Co-expression of Ptp61F^HMS00421 suppresses the loss of germline stem cells in testes with lid^GL00612 driven by Scer\GAL4^nos.PU.

(Tarayrah et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

36652

y¹ sc^* v¹ sev²¹; P{TRiP.GL00612}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Kdm5^GL00612

lid^GL00612

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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