FlyBase Allele Report: Dmel\cact[GL00627]

General Information

Symbol

Dmel\cact^GL00627

Species

D. melanogaster

Name

FlyBase ID

FBal0266326

Feature type

allele

Associated gene

Dmel\cact

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00627}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00627}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00627

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of collagen disease

CEA

(Zang et al., 2015)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of collagen disease

is ameliorated by PH4αEFB^GD771

(Zang et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

melanotic mass phenotype, with Scer\GAL4^{SPARC-MI00329-GAL4}

(Zang et al., 2015)

Phenotype Manifest In

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

(Zang et al., 2015)

fat body, with Scer\GAL4^{SPARC-MI00329-GAL4}

(Zang et al., 2015)

melanotic mass, with Scer\GAL4^{SPARC-MI00329-GAL4}

(Zang et al., 2015)

plasma membrane, with Scer\GAL4^{SPARC-MI00329-GAL4}

(Zang et al., 2015)

Detailed Description

Statement

Reference

Third larval instar adipocytes expressing cact^GL00627 under the control of Scer\GAL4^{SPARC-MI00329-GAL4} show a significant increase in both plasma membrane depth and sinuosity compared to control cells.

Expression of cact^GL00627 under the control of Scer\GAL4^{SPARC-MI00329-GAL4} results in melanisation of the fat body.

(Zang et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^{SPARC-MI00329-GAL4}, cact^GL00627 has plasma membrane phenotype, suppressible by Dif^HM05191, Scer\GAL4^{SPARC-MI00329-GAL4}

(Zang et al., 2015)

Scer\GAL4^{SPARC-MI00329-GAL4}, cact^GL00627 has plasma membrane phenotype, suppressible by Rab1^JF02609, Scer\GAL4^{SPARC-MI00329-GAL4}

(Zang et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The increase in plasma membrane depth seen in third larval instar adipocytes expressing cact^GL00627 under the control of Scer\GAL4^{SPARC-MI00329-GAL4} is suppressed by co-expression of either Rab1^JF02609 or Dif^HM05191.

(Zang et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

37484

y¹ sc^* v¹ sev²¹; P{TRiP.GL00627}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

cact^GL00627

(Rahimi et al., 2019)

cactⁱ

(Zang et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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