FlyBase Allele Report: Dmel\Patronin[HMS01547]

FB2025_02 , released April 17, 2025

FB2025_02 , released April 17, 2025

Allele: Dmel\Patronin^HMS01547

General Information

Symbol

Dmel\Patronin^HMS01547

Species

D. melanogaster

Name

FlyBase ID

FBal0266454

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01547}

Also Known As

patronin RNAi, UAS-Patronin.RNAi^{TRiP.HMS01547}

Key Links

Genomic Maps

Transgenic product class

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS01547}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity | larval stage, with Scer\GAL4⁴⁷⁷

(Wang et al., 2019)

abnormal cell shape | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

abnormal cell shape | pupal stage, with Scer\GAL4^ppk.PU

(Wang et al., 2019)

abnormal neuroanatomy | larval stage, with Scer\GAL4⁴⁷⁷

(Wang et al., 2019)

abnormal neuroanatomy | larval stage, with Scer\GAL4^RapGAP1-OK6

(Gao et al., 2024)

abnormal neuroanatomy | pupal stage, with Scer\GAL4^ppk.PU

(Wang et al., 2019)

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

(Sun et al., 2019)

decreased size | adult stage, with Scer\GAL4^nub.PU

(Yang and Choi, 2021)

increased cell death | larval stage, with Scer\GAL4^en.PU

(Yang and Choi, 2021)

visible | adult stage, with Scer\GAL4^en.PU

(Yang and Choi, 2021)

visible | adult stage, with Scer\GAL4^nub.PU

(Yang and Choi, 2021)

Phenotype Manifest In

apical part of cell | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

cell junction | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

dendrite | larval stage, with Scer\GAL4⁴⁷⁷

(Wang et al., 2019)

dendrite | pupal stage, with Scer\GAL4^ppk.PU

(Wang et al., 2019)

dendritic branch | larval stage, with Scer\GAL4²²¹

(Feng et al., 2021)

dorsal fold | ectopic | gastrula stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

epithelial cell | dorsal | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

epithelium | dorsal | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

fat cell | third instar larval stage, with Scer\GAL4^Cg.PA

(Sun et al., 2019)

filamentous actin | larval stage, with Scer\GAL4^RapGAP1-OK6

(Gao et al., 2024)

larval dorsal multidendritic neuron ddaC | larval stage, with Scer\GAL4⁴⁷⁷

(Wang et al., 2019)

larval dorsal multidendritic neuron ddaC | pupal stage, with Scer\GAL4^ppk.PU

(Wang et al., 2019)

larval dorsal multidendritic neuron ddaE, with Scer\GAL4²²¹

(Feng et al., 2021)

microtubule | embryonic stage | increased number | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

microtubule | larval stage, with Scer\GAL4⁴⁷⁷

(Wang et al., 2019)

microtubule | larval stage, with Scer\GAL4^ppk.PG

(Gao et al., 2024)

microtubule | larval stage, with Scer\GAL4^RapGAP1-OK6

(Gao et al., 2024)

microtubule | third instar larval stage, with Scer\GAL4^Cg.PA

(Sun et al., 2019)

microtubule bundle | larval stage, with Scer\GAL4²²¹

(Feng et al., 2021)

microtubule plus-end | larval stage, with Scer\GAL4²²¹

(Feng et al., 2021)

neuron projection | larval stage, with Scer\GAL4^RapGAP1-OK6

(Gao et al., 2024)

NMJ bouton | decreased number | larval stage, with Scer\GAL4^RapGAP1-OK6

(Gao et al., 2024)

nucleus | third instar larval stage, with Scer\GAL4^Cg.PA

(Sun et al., 2019)

plasma membrane | apical | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

wing, with Scer\GAL4^en.PU

(Yang and Choi, 2021)

wing, with Scer\GAL4^nub.PU

(Yang and Choi, 2021)

wing disc | larval stage, with Scer\GAL4^en.PU

(Yang and Choi, 2021)

Detailed Description

Statement

Reference

Class I neuron ddaE neurons expressing Patronin^HMS01547 under the control of Scer\GAL4²²¹ (together with Dicer-2 for a more efficient RNAi) show a higher rate of cell body-directed growing microtubules to successfully exit a distal or peripheral branch point, but not a proximal branch point; microtubule bundles form triangular arrangement of at dendrite branch points.

(Feng et al., 2021)

Third instar larval adipocytes expressing Patronin^HMS01547 under the control of Scer\GAL4^Cg.PA abolishes the strong perinuclear microtubule distribution normally observed in controls, also causing nuclear enlargement and misposition.

(Sun et al., 2019)

Expression of Patronin^HMS01547 under the control of Scer\GAL4^ppk.PU, in combination with a Dicer-2 transgene to enhance RNAi efficiency, results in failure to prune all ddaC dendrites by 16 h after puparium formation (APF), unlike controls.

Expression of Patronin^HMS01547 under the control of Scer\GAL4⁴⁷⁷ in larvae, in combination with a Dicer-2 transgene to enhance RNAi efficiency, results in a significant increase in plus-end out microtubules in ddaC dendrites, compared to controls.

(Wang et al., 2019)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} has abnormal cell shape | embryonic stage | maternal effect phenotype, non-enhanceable by baz^HMS01992, Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} has abnormal cell shape | embryonic stage | maternal effect phenotype, non-enhanceable by Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764/kat80^CPTI000764/Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

NOT suppressed by

Statement

Reference

Patronin^HMS01547, Scer\GAL4^RapGAP1-OK6 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by shot^GL01286, Scer\GAL4^RapGAP1-OK6

(Gao et al., 2024)

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} has abnormal cell shape | maternal effect | embryonic stage phenotype, non-suppressible by baz^HMS01992, Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} has abnormal cell shape | maternal effect | embryonic stage phenotype, non-suppressible by Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764/kat80^CPTI000764/Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

Enhancer of

Statement

Reference

Patronin^HMS01547, Scer\GAL4^RapGAP1-OK6 is an enhancer of abnormal neuroanatomy | larval stage phenotype of Scer\GAL4^RapGAP1-OK6, shot^GL01286

(Gao et al., 2024)

NOT Enhancer of

Statement

Reference

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} is a non-enhancer of abnormal cell shape | embryonic stage | maternal effect phenotype of Scer\GAL4^{VP16.mat.αTub67C}, Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764

(Takeda et al., 2018)

NOT Suppressor of

Statement

Reference

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} is a non-suppressor of abnormal cell shape | maternal effect | embryonic stage phenotype of Scer\GAL4^{VP16.mat.αTub67C}, Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764

(Takeda et al., 2018)

Phenotype Manifest In

Enhanced by

Statement

Reference

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} has cell junction | embryonic stage | maternal effect phenotype, enhanceable by baz^HMS01992, Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

NOT Enhanced by

Statement

Reference

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} has cell junction | embryonic stage | maternal effect phenotype, non-enhanceable by Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764/kat80^CPTI000764/Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} has dorsal fold | gastrula stage | ectopic | maternal effect phenotype, non-enhanceable by Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764/kat80^CPTI000764/Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} has epithelial cell | embryonic stage | dorsal | maternal effect phenotype, non-enhanceable by Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764/kat80^CPTI000764/Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} has epithelium | embryonic stage | dorsal | maternal effect phenotype, non-enhanceable by Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764/kat80^CPTI000764/Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

Suppressed by

Statement

Reference

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} has dorsal fold | ectopic | maternal effect | gastrula stage phenotype, suppressible by baz^HMS01992, Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

NOT suppressed by

Statement

Reference

Patronin^HMS01547, Scer\GAL4^RapGAP1-OK6 has NMJ bouton | larval stage phenotype, non-suppressible by shot^GL01286, Scer\GAL4^RapGAP1-OK6

(Gao et al., 2024)

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} has cell junction | maternal effect | embryonic stage phenotype, non-suppressible by Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764/kat80^CPTI000764/Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} has dorsal fold | ectopic | maternal effect | gastrula stage phenotype, non-suppressible by Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764/kat80^CPTI000764/Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} has epithelial cell | dorsal | maternal effect | embryonic stage phenotype, non-suppressible by Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764/kat80^CPTI000764/Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} has epithelium | dorsal | maternal effect | embryonic stage phenotype, non-suppressible by Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764/kat80^CPTI000764/Scer\GAL4^{VP16.mat.αTub67C}

(Takeda et al., 2018)

Enhancer of

Statement

Reference

Patronin^HMS01547, Scer\GAL4^RapGAP1-OK6 is an enhancer of NMJ bouton | larval stage phenotype of Scer\GAL4^RapGAP1-OK6, shot^GL01286

(Gao et al., 2024)

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} is an enhancer of cell junction | embryonic stage | maternal effect phenotype of Scer\GAL4^{VP16.mat.αTub67C}, baz^HMS01992

(Takeda et al., 2018)

NOT Enhancer of

Statement

Reference

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} is a non-enhancer of epithelial cell | embryonic stage | dorsal | maternal effect phenotype of Scer\GAL4^{VP16.mat.αTub67C}, Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764

(Takeda et al., 2018)

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} is a non-enhancer of epithelium | embryonic stage | dorsal | maternal effect phenotype of Scer\GAL4^{VP16.mat.αTub67C}, Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764

(Takeda et al., 2018)

Suppressor of

Statement

Reference

Patronin^HMS01547, Scer\GAL4^Cg.PA is a suppressor of fat cell | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^GL01286

(Sun et al., 2019)

Patronin^HMS01547, Scer\GAL4^Cg.PA is a suppressor of nucleus | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^GL01286

(Sun et al., 2019)

Patronin^HMS01547, Scer\GAL4^Cg.PA is a suppressor | partially of microtubule | third instar larval stage phenotype of Scer\GAL4^Cg.PA, shot^GL01286

(Sun et al., 2019)

NOT Suppressor of

Statement

Reference

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} is a non-suppressor of epithelial cell | dorsal | maternal effect | embryonic stage phenotype of Scer\GAL4^{VP16.mat.αTub67C}, Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764

(Takeda et al., 2018)

Patronin^HMS01547, Scer\GAL4^{VP16.mat.αTub67C} is a non-suppressor of epithelium | dorsal | maternal effect | embryonic stage phenotype of Scer\GAL4^{VP16.mat.αTub67C}, Zzzz\VHH^{deGradFP.UASp.cHa}, kat80^CPTI000764

(Takeda et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Patronin^HMS01547

(Zheng et al., 2020)

Patronin^i-1753

(Sun et al., 2021)

Patroninⁱ

(Sun et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections