FlyBase Allele Report: Dmel\NP15.6[HMS01560]

General Information

Symbol

Dmel\NP15.6^HMS01560

Species

D. melanogaster

Name

FlyBase ID

FBal0266467

Feature type

allele

Associated gene

Dmel\NP15.6

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01560}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS01560}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01560

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

short lived, with Scer\GAL4^Tub.PU

(Parkhitko et al., 2020)

visible | adult stage, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

Phenotype Manifest In

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

eye, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

mitochondrial crista | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

mitochondrion | third instar larval stage, with Scer\GAL4^Cg.PA

(Zhou et al., 2019)

Detailed Description

Statement

Reference

Expression of NP15.6^HMS01560 under the control of Scer\GAL4^Tub.PU (in combination with tub-Gal80[ts] to restrict expression to adult stages) leads to a decrease in lifespan.

(Parkhitko et al., 2020)

Expression under the control of Scer\GAL4^eya.enh1+E+2 results in a glossy eye phenotype.

(Pletcher et al., 2019)

Expressing NP15.6^HMS01560 under the control of Scer\GAL4^Cg.PA leads to swollen mitochondria, with few cristae, in the third instar larval fat body (as assessed by MitoGFP and EM).

(Zhou et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions