FB2025_01 , released February 20, 2025
Allele: Dmel\zipHMS01618
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General Information
Symbol
Dmel\zipHMS01618
Species
D. melanogaster
Name
FlyBase ID
FBal0266525
Feature type
allele
Associated gene
Dmel\zip
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS01618}
Also Known As
zip RNAi, zip-RNAi, UAS-zip-RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2011.7.19)
Mutagen
in vitro construct
(Ni et al., 2011.7.19)
Progenitor genotype
Carried in construct
P{TRiP.HMS01618}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS01618
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult flies expressing zipHMS01618 under the control of Scer\GAL4Dot.PK display nephrocyte functional defects (measured by uptake assays) and reduced adult lifespan relative to controls.

      (Fu et al., 2017)

      Expression of zipHMS01618 under the control of Scer\GAL4GMR.PU results in fused rhabdomeres.

      (Nie et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      zipHMS01618/Scer\GAL4GMR.PU is an enhancer of retina phenotype of eys1, prom[+]/prom1

      (Nie et al., 2014)
      Other
      Statement
      Reference

      eys[+]/eys1, zipHMS01618 has retina phenotype

      (Nie et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of zipHMS01618 under the control of Scer\GAL4GMR.PU enhances the rhabdomere fusion seen in eys1 prom1 double heterozygotes.

      Expression of zipHMS01618 under the control of Scer\GAL4GMR.PU in a eys1 mutant background results in fused rhabdomeres as early as 48 hours after pupal formation.

      (Nie et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      zipHMS01618
      Name Synonyms
      Secondary FlyBase IDs
        References (14)