FlyBase Allele Report: Dmel\Ire1[HMS03003]

General Information

Symbol

Dmel\Ire1^HMS03003

Species

D. melanogaster

Name

FlyBase ID

FBal0266575

Feature type

allele

Associated gene

Dmel\Ire1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS03003}

Also Known As

HMS03003

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS03003}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS03003

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye-antennal disc | somatic clone, with Scer\GAL4^Act.PU

(Zheng et al., 2023)

Detailed Description

Statement

Reference

Expressing Ire1^HMS03003 under the control of Scer\GAL4^Ddc.PU does not affect lifespan, adult climbing ability or number of DA neurons.

(Yan et al., 2019)

Females heterozygous for Ire1^HMS03003 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to Ire1^HMS03003 males results in: 78% hatching; non-maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/Ire1^HMS03003 is an enhancer of decreased cell number | larval stage | somatic clone phenotype of scrib¹

(Zheng et al., 2023)

Suppressor of

Statement

Reference

Ire1^HMS03003, Scer\GAL4^Ddc.PU is a suppressor of short lived phenotype of Hsap\SNCA^A30P.UAS, Scer\GAL4^Ddc.PU

(Yan et al., 2019)

Ire1^HMS03003, Scer\GAL4^Ddc.PU is a suppressor of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\SNCA^A30P.UAS, Scer\GAL4^Ddc.PU

(Yan et al., 2019)

Ire1^HMS03003, Scer\GAL4^Ddc.PU is a suppressor of decreased cell number | adult stage | progressive phenotype of Hsap\SNCA^A30P.UAS, Scer\GAL4^Ddc.PU

(Yan et al., 2019)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/Ire1^HMS03003 is an enhancer of eye-antennal disc | somatic clone phenotype of scrib¹

(Zheng et al., 2023)

Suppressor of

Statement

Reference

Ire1^HMS03003, Scer\GAL4^GMR.long is a suppressor | partially of ommatidium | progressive phenotype of Hsap\SNCA^A30P.UAS, Scer\GAL4^GMR.long

(Yan et al., 2019)

Ire1^HMS03003, Scer\GAL4^GMR.long is a suppressor | partially of retina | progressive phenotype of Hsap\SNCA^A30P.UAS, Scer\GAL4^GMR.long

(Yan et al., 2019)

Ire1^HMS03003, Scer\GAL4^Ddc.PU is a suppressor of dopaminergic PPM3 neuron | progressive phenotype of Hsap\SNCA^A30P.UAS, Scer\GAL4^Ddc.PU

(Yan et al., 2019)

Ire1^HMS03003, Scer\GAL4^GMR.long is a suppressor | partially of ommatidium | progressive phenotype of Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.long

(Yan et al., 2019)

Ire1^HMS03003, Scer\GAL4^GMR.long is a suppressor | partially of retina | progressive phenotype of Hsap\SNCA^A53T.UAS, Scer\GAL4^GMR.long

(Yan et al., 2019)

Ire1^HMS03003, Scer\GAL4^GMR.long is a suppressor | partially of retina | progressive phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.long

(Yan et al., 2019)

Ire1^HMS03003, Scer\GAL4^GMR.long is a suppressor | partially of ommatidium | progressive phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.long

(Yan et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Ire1^HMS03003/Scer\GAL4^GMR.long rescues Ire1^UAS.Tag:V5

(Yan et al., 2019)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

36743

y¹ sc^* v¹ sev²¹; P{TRiP.HMS03003}attP40

NIG-Fly

HMS03003

y¹ sc^* v¹ sev²¹; P{TRiP.HMS03003}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ire1^HMS03003

ire1^RNAi-1

(Zhao et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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