FB2025_01 , released February 20, 2025
Allele: Dmel\MybPP374.UAS.EGFP
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General Information
Symbol
Dmel\MybPP374.UAS.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0266823
Feature type
allele
Associated gene
Dmel\Myb
Associated Insertion(s)
Carried in Construct
P{UAS-Myb.PP374.eGFP}
Key Links
Transgenic product class
missense_variant
(Andrejka et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Andrejka et al., 2011)
Mutagen
in vitro construct
(Andrejka et al., 2011)
Progenitor genotype
MybUAS.N.EGFP
(Andrejka et al., 2011)
Carried in construct
P{UAS-Myb.PP374.eGFP}
Cytology
Description

UAS regulatory sequences drive expression of a mutant form of Myb in which the PP amino acid sequence starting at position 374 has been replaced with AA. The construct is tagged at the N-terminus with EGFP.

(Andrejka et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Myb
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing MybPP374.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4da.G32 do not display any obvious phenotypes at 29[o]C.

      (Andrejka et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4da.G32/MybPP374.UAS.EGFP partially rescues MybMH107

      (Andrejka et al., 2011)
      Comments

      Expression of MybPP374.Scer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4da.G32 partially rescues MybMH107 mutant lethality at 25[o]C, resulting in approximately 50% of the number of adult flies seen in wild type. The rescue is much weaker at 29[o]C.

      (Andrejka et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MybPP374.Scer\UAS.T:Avic\GFP-EGFP
      MybPP374.UAS.EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)