FB2025_02 , released April 17, 2025
Allele: Dmel\HemUAS.ΔJ4-48
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General Information
Symbol
Dmel\HemUAS.ΔJ4-48
Species
D. melanogaster
Name
FlyBase ID
FBal0267024
Feature type
allele
Associated gene
Dmel\Hem
Associated Insertion(s)
Carried in Construct
P{UAS-Hem.Δ}
Key Links
Transgenic product class
inframe_deletion
(Zhu and Bhat, 2011)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Zhu and Bhat, 2011)
Mutagen
in vitro construct
(Zhu and Bhat, 2011)
Progenitor genotype
Carried in construct
P{UAS-Hem.Δ}
Cytology
Description

UAS regulatory sequences drive expression of a truncated form of Hem corresponding to the coding fragment of the first 489 amino acids.

(Zhu and Bhat, 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hem
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Less than 1% of embryos expressing HemScer\UAS.ΔJ4-48 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 display an RP2 neuron defect in which a duplication is seen in one hemisegment and have one missing in the contralateral segment.

      17% of embryos expressing HemScer\UAS.ΔJ4-48 under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 in a HemJ4-48/Df(3L)ED230 mutant background display an RP2 neuron defect in which a duplication is seen in one hemisegment and have one missing in the contralateral segment. The GMC is formed in both hemisegments and divides normally into an RP2 and a sib cell. The RP2 duplication occurs due to aberrant crossing of the midline at 11hr of development. The sib cell remains in the correct hemisegment.

      (Zhu and Bhat, 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HemScer\UAS.ΔJ4-48
      HemUAS.ΔJ4-48
      Name Synonyms
      Secondary FlyBase IDs
        References (1)