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General Information
Symbol
Dmel\Toll-7UAS.cYa
Species
D. melanogaster
Name
FlyBase ID
FBal0267033
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Toll-7
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of Toll-7 coding sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Toll-7Scer\UAS.cYa under the control of Scer\GAL4AM29 results in a severe lateral mistargeting of DM6 olfactory neuron axons to the Toll-7-expressing region. Targeting of DL4 olfactory neuron axons is unaffected.

Expression of Toll-7Scer\UAS.cYa under the control of Scer\GAL4AM29 in homozygous Df(2R)Toll-7AW1 animals results in lateral mistargeting of DM6 olfactory receptor neuron axons. These mistargeted axons intermingle extensively with Scer\GAL4Mz19-positive projection neuron dendrites.

Compared with wild-type, flies overexpressing Scer\GAL4hs.PU>Toll-7Scer\UAS.cYa show moderately enhanced survival after infection with Rift Valley Fever Virus (RVFV).

Expression of Toll-7Scer\UAS.cYa under the control of Scer\GAL4da.G32 results in mild defects in abdominal closure, extra bristles, rough eyes and wing vein thickening. The penetrance of the rough eye phenotype is close to 100% while the penetrance of other phenotypes is approximately 5-10%.

Expression of Toll-7Scer\UAS.cYa under the control of Scer\GAL432B results in mild defects in an abdominal closure defect, extra bristles and a rough eye phenotype.

Expression of Toll-7Scer\UAS.cYa under the control of Scer\GAL471B generates an extra bristle phenotype.

Expression of Toll-7Scer\UAS.cYa under the control of Scer\GAL4dpp.PS generates a mild bifurcated wing phenotype, with a split occurring at the distal end of the wing along the anterior-posterior boundary, along with a leg defect phenotype. This defect can be traced to the imaginal disc stage, where abnormal folding at the anterior-posterior boundary is found.

Expression of Toll-7Scer\UAS.cYa under the control of either Scer\GAL4GMR.PF or Scer\GAL4lz-gal4 results in a rough eye phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Toll-7Scer\UAS.cYa under the control of Scer\GAL4Mz19 rescues the VA1d olfactory receptor neuron axon targeting defects seen in Toll-6ex13 mutants.

Expression of Toll-7Scer\UAS.cYa under the control of Scer\GAL4Mz19 also rescues the mistargeting of VA1d and DC3 projection neuron dendrites which is seen in Toll-6ex13 adNb clones.

Expression of Toll-7Scer\UAS.cYa under the control of Scer\GAL4AM29 in homozygous Df(2R)Toll-7AW1 animals results in extensive intermingling of mistargeted DM6 olfactory receptor neuron axons with Scer\GAL4Mz19-positive projection neuron dendrites. This intermingling is still seen if the flies are also carrying Toll-6ex13 mutant adNb clones.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Toll-7Scer\UAS.cYa under the control of Scer\GAL4peb-GAL4 rescues the VA1d olfactory receptor neuron targeting defects seen in Df(2R)Toll-7AW1 mutants.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Toll-7Scer\UAS.cYa
Toll-7UAS.cYa
Name Synonyms
Secondary FlyBase IDs
    References (3)