FlyBase Allele Report: Dmel\Tollo[UAS.cYa]

General Information

Symbol

Dmel\Tollo^UAS.cYa

Species

D. melanogaster

Name

FlyBase ID

FBal0267035

Feature type

allele

Associated gene

Dmel\Tollo

Associated Insertion(s)

Carried in Construct

P{UAS-Tollo.Y}

Key Links

Transgenic product class

wild_type

(Yagi et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Yagi et al., 2010)

Mutagen

in vitro construct

(Yagi et al., 2010)

Progenitor genotype

Carried in construct

P{UAS-Tollo.Y}

Cytology

Description

UASt regulatory sequences drive expression of Tollo coding sequences.

(Yagi et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Tollo

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage, with Scer\GAL4^AM29

(Ward et al., 2015)

lethal, with Scer\GAL4^e22c

(Yagi et al., 2010)

Phenotype Manifest In

adult abdomen, with Scer\GAL4^32B

(Yagi et al., 2010)

adult abdomen, with Scer\GAL4^71B

(Yagi et al., 2010)

adult abdomen, with Scer\GAL4^da.G32

(Yagi et al., 2010)

adult olfactory receptor neuron Or67a, with Scer\GAL4^AM29

(Ward et al., 2015)

eye, with Scer\GAL4^32B

(Yagi et al., 2010)

eye, with Scer\GAL4^da.G32

(Yagi et al., 2010)

eye, with Scer\GAL4^GMR.PF

(Yagi et al., 2010)

eye, with Scer\GAL4^lz-gal4

(Yagi et al., 2010)

leg, with Scer\GAL4^32B

(Yagi et al., 2010)

leg, with Scer\GAL4^dpp.PS

(Yagi et al., 2010)

leg, with Scer\GAL4^ptc-559.1

(Yagi et al., 2010)

leg disc, with Scer\GAL4^dpp.PS

(Yagi et al., 2010)

macrochaeta | ectopic, with Scer\GAL4^32B

(Yagi et al., 2010)

macrochaeta | ectopic, with Scer\GAL4^71B

(Yagi et al., 2010)

macrochaeta | ectopic, with Scer\GAL4^da.G32

(Yagi et al., 2010)

wing, with Scer\GAL4^32B

(Yagi et al., 2010)

wing, with Scer\GAL4^71B

(Yagi et al., 2010)

wing, with Scer\GAL4^dpp.PS

(Yagi et al., 2010)

wing, with Scer\GAL4^ptc-559.1

(Yagi et al., 2010)

wing disc, with Scer\GAL4^dpp.PS

(Yagi et al., 2010)

wing vein, with Scer\GAL4^32B

(Yagi et al., 2010)

wing vein, with Scer\GAL4^71B

(Yagi et al., 2010)

wing vein, with Scer\GAL4^da.G32

(Yagi et al., 2010)

Detailed Description

Statement

Reference

Expression of Tollo^Scer\UAS.cYa under the control of Scer\GAL4^AM29 results in lateral mistargeting of DM6 olfactory neuron axons.

(Ward et al., 2015)

Expression of Tollo^Scer\UAS.cYa under the control of Scer\GAL4^da.G32 results in mild defects in abdominal closure, extra bristles, rough eyes and wing vein thickening. The penetrance of the rough eye phenotype is close to 100% while the penetrance of other phenotypes is approximately 5-10%.

Expression of Tollo^Scer\UAS.cYa under the control of Scer\GAL4^32B results in mild defects in abdominal closure, extra bristles, rough eyes, leg defects, wing vein thickening, a notched wing, and a black cell-like phenotype.

Expression of Tollo^Scer\UAS.cYa under the control of Scer\GAL4^71B results in mild defects in abdominal closure, extra bristles in some areas of the abdomen and a loss of bristles in other areas, wing vein thickening, and a notched wing phenotype.

Expression of Tollo^Scer\UAS.cYa under the control of Scer\GAL4^dpp.PS generates a bifurcated wing phenotype and leg defects. This defect can be traced to the imaginal disc stage, where abnormal folding at the anterior-posterior boundary is found.

Expression of Tollo^Scer\UAS.cYa under the control of Scer\GAL4^ptc-559.1 generates a bifurcated wing phenotype, a black cells-like phenotype and leg defects.

Expression of Tollo^Scer\UAS.cYa under the control of either Scer\GAL4^GMR.PF or Scer\GAL4^lz-gal4 generates a rough eye phenotype.

(Yagi et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Scer\GAL4^dpp.PS, Tollo^UAS.cYa has wing phenotype, non-suppressible by Myd88^EP2133

(Yagi et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

A Myd88^EP2133 homozygous background does not suppress the bifurcated wing phenotype seen upon expression of Tollo^Scer\UAS.cYa under the control of Scer\GAL4^dpp.PS.

(Yagi et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Tollo^Scer\UAS.cYa

Tollo^UAS.cYa

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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