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General Information
Symbol
Dmel\Atg1UAS.cCa
Species
D. melanogaster
Name
FlyBase ID
FBal0267076
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Atg1
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of Atg1.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Atg1Scer\UAS.cCa under the control of Scer\GAL4elav-C155 reduces bouton size compared to controls.

Expression of Atg1Scer\UAS.cCa under the control of either Scer\GAL4esg-NP5130 results in impaired intestinal stem cell proliferation in response to paraquat.

Overexpression of Atg1Scer\UAS.cCa in third instar wing imaginal discs under the control of Scer\GAL4ptc-559.1 leads to abnormal cell morphology and F-actin reorganisation.

Overexpression of Atg1Scer\UAS.cCa under the control of Scer\GAL4ptc-559.1 results in the disappearance of anterior crossveins in adult wings.

Overexpression of Atg1Scer\UAS.cCa in developing wing imaginal discs under the control of Scer\GAL4ptc-559.1 induces a marked increase in autophagosome formation and increased cell death compared to controls.

Overexpression of Atg1Scer\UAS.cCa by the Scer\GAL4ptc-559.1 driver results in missing anterior crossveins, wing hair polarity defects and the loss of macrochaetae.

Flies expressing both Atg1Scer\UAS.cCa and Atg1dsRNA.Scer\UAS under the control of Scer\GAL4ptc-559.1 exhibit normal wings.

Flies expressing Atg1Scer\UAS.cCa under the control of either Scer\GAL4ptc-559.1 or Scer\GAL4en-e16E are largely viable.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Atg1Scer\UAS.cCa suppresses the enlarged bouton phenotype seen when Vap-33AP58S.cRa.Scer\UAS is expressed under the control of Scer\GAL4elav-C155.

Expression of Atg1Scer\UAS.cCa suppresses the small bouton phenotype seen when Vap-33AScer\UAS.cRa is expressed under the control of Scer\GAL4elav-C155.

Co-expression of sqadsRNA.Scer\UAS with Atg1Scer\UAS.cCa under the control of Scer\GAL4ptc-559.1 suppresses the anterior crossvein phenotype resulting from the overexpression of Atg1Scer\UAS.cCa alone.

Flies overexpressing both PaxScer\UAS.cCa and Atg1Scer\UAS.cCa under the control of Scer\GAL4ptc-559.1 show increased lethality, compared to lines overexpressing either transgene alone. Over 90% of the flies expressing both PaxScer\UAS.cCa and Atg1Scer\UAS.cCa die at pupal stages.

Flies overexpressing both PaxScer\UAS.cCa and Atg1Scer\UAS.cCa under the control of Scer\GAL4en-e16E show increased lethality, compared to lines overexpressing either transgene alone.

Aristae of flies overexpressing both PaxScer\UAS.cCa and Atg1Scer\UAS.cCa driven by Scer\GAL4ptc-559.1 are often missing or greatly shortened.

One copy of EcR225 suppresses the Scer\GAL4ptc-559.1-driven Atg1Scer\UAS.cCa-induced wing defects.

Overexpression of bsScer\UAS.cHa significantly suppresses the Scer\GAL4ptc-559.1-driven Atg1Scer\UAS.cCa-induced wing defects.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Atg1Scer\UAS.cCa
Atg1UAS.cCa
Name Synonyms
Secondary FlyBase IDs
    References (5)