Allele Dmel\CkIα^8B12

General Information
Symbol	Dmel\CkIα^8B12	Species	D. melanogaster
Name		FlyBase ID	FBal0267315
Feature type	allele	Associated gene	Dmel\CkIα

Allele class	amorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Legent et al., 2012)
Mutagen	ethyl methanesulfonate (Legent et al., 2012)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: G43D. (Legent et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage (Legent et al., 2012) lethal \| larval stage (Legent et al., 2012) visible \| somatic clone (Legent et al., 2012)
Phenotype Manifest In
	eye \| somatic clone (Legent et al., 2012) eye disc \| somatic clone \| third instar larval stage (Legent et al., 2012) wing \| somatic clone (Legent et al., 2012)
Detailed Description
	Statement Reference Homozygous clones in the adult eye have cuticle protrusions in the retina. Homozygous clones in the third larval instar eye disc completely lack photoreceptors, overgrow and have smooth borders. Homozygous clones in the wing blade differentiate ectopic bristles. Homozygotes die primarily during embryogenesis and early larval stages, but show no obvious cuticle patterning defects. (Legent et al., 2012)
External Data
Linkouts
Interactions
Phenotypic Class
NOT suppressed by
Statement Reference CkIα^8B12 has lethal phenotype, non-suppressible by CG2577^{Scer\UAS.T:Zzzz\FLAG}/Scer\GAL4^tub.PU (Legent et al., 2012) CkIα^8B12 has lethal phenotype, non-suppressible by dco^KD.Scer\UAS/Scer\GAL4^tub.PU (Legent et al., 2012)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	CkIα^8B12 is rescued by CkIα^{Scer\UAS.T:Zzzz\FLAG}/Scer\GAL4^tub.PU (Legent et al., 2012)
Comments	Expression of CkIα[Scer\UAS.T:Zzzz\FLAG] under the control of Scer\GAL4[tub.PU] rescues the lethality of CkIα[8B12] flies. (Legent et al., 2012)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CK1α^8B12 (Legent et al., 2012) CkIα^8B12
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Legent et al., 2012, Genetics 190(2): 601--616 A screen for x-linked mutations affecting Drosophila photoreceptor differentiation identifies casein kinase 1α as an essential negative regulator of wingless signaling. [FBrf0217484]

Allele Dmel\CkIα8B12

Allele Dmel\CkIα^8B12