Allele Dmel\brp^nude

General Information
Symbol	Dmel\brp^nude	Species	D. melanogaster
Name		FlyBase ID	FBal0267420
Feature type	allele	Associated gene	Dmel\brp

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: ?1724@. (Hallermann et al., 2010) Mutagenesis leads to a premature STOP codon at amino acid position 1724 (out of 1740). (Hallermann et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	locomotor rhythm defective (Hallermann et al., 2010) neurophysiology defective (Hallermann et al., 2010) short lived (Hallermann et al., 2010)
Phenotype Manifest In
	neuromuscular junction (Hallermann et al., 2010) synapse (Hallermann et al., 2010) synaptic vesicle (Hallermann et al., 2010)
Detailed Description
	Statement Reference brp[nude] mutants exhibit significantly reduced survival rates and motor abilities. brp[nude] mutant neuromuscular junctions exhibit a normal number of active zones and normal cytomatrix distribution, with wild-type levels of dense bodies. Furthermore, the diameter of the synaptic vesicles as well as the total number of synaptic vesicles per bouton section are unchanged in brp[nude] mutants. brp[nude] mutant synapses display normal Ca[2+] channel distribution. EPSCs evoked at 0.2Hz at brp[nude] mutant synapses do not differ in terms of their peak amplitude, rise time, or decay time constant from those of controls. Depression decay during paired-pulse stimulation is stronger in brp[nude] mutants, as quantified by a reduction in the steady-state EPSC amplitude at the end of the train to 35% compared to 52% in controls. Consistent with the altered paired-pulse ratio, the amplitude of the second EPSC in the train is already significantly reduced to 80% at brp[nude] synapses. brp[nude] mutant synapses display enhanced depression during sustained high frequency transmission. Consistently, the first component of recovery is slower, whilst the second component is unaltered. (Hallermann et al., 2010)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	brp^5.38 (Hallermann et al., 2010) brp^nude (Hallermann et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Hallermann et al., 2010, J. Neurosci. 30(43): 14340--14345 Naked dense bodies provoke depression. [FBrf0214096]

Allele Dmel\brpnude

Allele Dmel\brp^nude