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General Information
Symbol
Hsap\LYZUAS.Tag:SS(nec)
Species
H. sapiens
Name
FlyBase ID
FBal0267429
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of Hsap\LYZ with an insect secretion signal (Tag:SS(nec)) fused to its N-terminus.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Hsap\LYZScer\UAS.T:SS-nec under the control of Scer\GAL4nSyb.PS does not significantly affect adult lifespan, nor does it induce apoptosis in the adult brain.

Expression of Hsap\LYZScer\UAS.T:SS-nec under the control of Scer\GAL4elav-C155 does not result in a significant decrease in lifespan, as compared to controls.

Expression of Hsap\LYZScer\UAS.T:SS-nec under the control of Scer\GAL4Act5C.PU leads to semi-lethality during methamorphosis.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Co-expression of Hsap\LYZScer\UAS.T:SS-nec and Hsap\APCSScer\UAS.cAa under the control of Scer\GAL4nSyb.PS does not affect adult lifespan, nor does it cause any cell death in the adult brain.

Co-expression of Hsap\LYZScer\UAS.T:SS-nec suppresses the decrease in lifespan and partially suppresses the locomotor defects seen in flies expressing Hsap\APPAβ42.Scer\UAS.T:SS-nec under the control of Scer\GAL4elav-C155.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Hsap\LYZScer\UAS.T:SS-nec
Hsap\LYZUAS.Tag:SS(nec)
Name Synonyms
Secondary FlyBase IDs
    References (4)