FB2025_01 , released February 20, 2025
Allele: Hsap\LYZUAS.Tag:SS(nec)
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General Information
Symbol
Hsap\LYZUAS.Tag:SS(nec)
Species
H. sapiens
Name
FlyBase ID
FBal0267429
Feature type
allele
Associated gene
Hsap\LYZ
Associated Insertion(s)
Carried in Construct
P{UAS-LYZ.SS-nec}
Also Known As
UAS-lysozyme
Key Links
Transgenic product class
wild_type
(Kumita et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kumita et al., 2012)
Mutagen
in vitro construct
(Kumita et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-LYZ.SS-nec}
Cytology
Description

UAS regulatory sequences drive expression of Hsap\LYZ with an insect secretion signal (Tag:SS(nec)) fused to its N-terminus.

(Kumita et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\LYZ
Tagged with
Tag:SS(nec)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\LYZScer\UAS.T:SS-nec under the control of Scer\GAL4nSyb.PS does not significantly affect adult lifespan, nor does it induce apoptosis in the adult brain.

      (Helmfors et al., 2016)

      Expression of Hsap\LYZScer\UAS.T:SS-nec under the control of Scer\GAL4elav-C155 does not result in a significant decrease in lifespan, as compared to controls.

      (Helmfors et al., 2015)

      Expression of Hsap\LYZScer\UAS.T:SS-nec under the control of Scer\GAL4Act5C.PU leads to semi-lethality during methamorphosis.

      (Kumita et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Hsap\LYZScer\UAS.T:SS-nec and Hsap\APCSScer\UAS.cAa under the control of Scer\GAL4nSyb.PS does not affect adult lifespan, nor does it cause any cell death in the adult brain.

      (Helmfors et al., 2016)

      Co-expression of Hsap\LYZScer\UAS.T:SS-nec suppresses the decrease in lifespan and partially suppresses the locomotor defects seen in flies expressing Hsap\APPAβ42.Scer\UAS.T:SS-nec under the control of Scer\GAL4elav-C155.

      (Helmfors et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\LYZScer\UAS.T:SS-nec
      Hsap\LYZUAS.Tag:SS(nec)
      wt lysozyme
      (Helmfors et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)