FlyBase Allele Report: Scer\NDI1[UAS.cVa]

General Information

Symbol

Scer\NDI1^UAS.cVa

Species

S. cerevisiae

Name

Saccharomyces cerevisiae UAS construct a of Vilain

FlyBase ID

FBal0267494

Feature type

allele

Associated gene

Scer\NDI1

Associated Insertion(s)

Carried in Construct

PBac{UAS-NDI1.V}

Transgenic product class

wild_type

(Vilain et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Vilain et al., 2012)

Mutagen

in vitro construct

(Vilain et al., 2012)

Progenitor genotype

Carried in construct

PBac{UAS-NDI1.V}

Cytology

Description

UAS regulatory sequences drive expression of Scer\NDI1.

(Vilain et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Scer\NDI1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Pink1^B9

(Vilain et al., 2012)

ameliorates nuclear type mitochondrial complex I deficiency 5

modeled by ND-75^HMS00853

(Granat et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\NDI1^UAS.cVa/Scer\GAL4^Act5C.PI is a suppressor | partially of abnormal neurophysiology | progressive phenotype of iPLA2-VIA^Δ174

(Lin et al., 2018)

Scer\NDI1^UAS.cVa/Scer\GAL4^da.PU is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Pogson et al., 2014)

Scer\NDI1^UAS.cVa/Scer\GAL4^da.PU is a suppressor | partially of abnormal flight phenotype of Pink1^B9

(Pogson et al., 2014)

Scer\NDI1^UAS.cVa is a suppressor of male sterile phenotype of Pink1^B9

(Vilain et al., 2012)

Scer\NDI1^UAS.cVa/Scer\GAL4^da.G32 is a suppressor | partially of abnormal flight phenotype of Pink1^B9

(Vilain et al., 2012)

Scer\NDI1^UAS.cVa, Scer\GAL4^da.G32 is a suppressor of abnormal flight phenotype of ND-15^GD4800, Scer\GAL4^da.G32

(Vilain et al., 2012)

NOT Suppressor of

Statement

Reference

Scer\NDI1^UAS.cVa is a non-suppressor of male sterile phenotype of park^Δ21/park¹

(Vilain et al., 2012)

Scer\NDI1^UAS.cVa/Scer\GAL4^da.G32 is a non-suppressor of abnormal flight phenotype of park^Δ21/park¹

(Vilain et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\NDI1^UAS.cVa/Scer\GAL4^Act5C.PI is a suppressor | partially of retina | progressive phenotype of iPLA2-VIA^Δ174

(Lin et al., 2018)

Scer\NDI1^UAS.cVa/Scer\GAL4^da.G32 is a suppressor | partially of mitochondrion phenotype of Pink1^B9

(Vilain et al., 2012)

Scer\NDI1^UAS.cVa/Scer\GAL4^da.G32 is a suppressor | partially of indirect flight muscle cell phenotype of Pink1^B9

(Vilain et al., 2012)

Scer\NDI1^UAS.cVa, Scer\GAL4^da.G32 is a suppressor of mitochondrion phenotype of ND-30^GD5910, Scer\GAL4^da.G32

(Vilain et al., 2012)

NOT Suppressor of

Statement

Reference

Scer\NDI1^UAS.cVa/Scer\GAL4^da.G32 is a non-suppressor of mitochondrion phenotype of park^Δ21/park¹

(Vilain et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Ubiquitous expression of Scer\NDI1^Scer\UAS.cVa under the control of Scer\GAL4^da.PU partially rescues the climbing defects seen in Pink1^B9 mutant flies. The flight defects are not significantly rescued.

(Pogson et al., 2014)

Scer\NDI1^Scer\UAS.cVa (in the absence of a Scer\GAL4 driver) rescues the sterility of Pink1^B9 male flies.

Expression of Scer\NDI1^Scer\UAS.cVa under the control of Scer\GAL4^da.G32 partially suppresses the flight defects of Pink1^B9 flies.

The mild flight defects observed under "stringent" testing conditions in flies expressing CG11455^GD4800 under the control of Scer\GAL4^da.G32 are suppressed by co-expression of Scer\NDI1^Scer\UAS.cVa.

Co-expression of Scer\NDI1^Scer\UAS.cVa suppresses the defects in mitochondrial morphology which are seen in the muscles of third instar larvae expressing CG12079^GD5910 under the control of Scer\GAL4^da.G32.

Scer\NDI1^Scer\UAS.cVa in the absence of a Scer\GAL4 driver does not suppress the sterility of park¹/park^Δ21 males (even though Scer\NDI1^Scer\UAS.cVa in the absence of a Scer\GAL4 driver does suppress the male sterility of Pink1^B9 males).

Expression of Scer\NDI1^Scer\UAS.cVa under the control of Scer\GAL4^da.G32 does not suppress the flight defects or defects in mitochondrial morphology which are seen in park¹/park^Δ21 flies.

(Vilain et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

605377

w^*; PBac{UAS-NDI1.V}VK00001

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Scer\NDI1^Scer\UAS.cVa

Scer\NDI1^UAS.cVa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Vilain

Secondary FlyBase IDs

References (4)

Report Sections

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