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General Information
Symbol
Dmel\CoRestGF60
Species
D. melanogaster
Name
FlyBase ID
FBal0267495
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

G19523435A

Comment:

G to A mutation in the first nucleotide of the third intron, resulting in a non-functional splice donor site.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

G to A mutation in the first nucleotide of the third intron, resulting in a non-functional splice donor site. RT-PCR analysis shows that the third intron is retained, and the presence of in an in-frame stop codon at the end of the third intron results in a truncated protein, lacking known functional domains. All three splice variants identified are affected by the mutation.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous posterior follicle cells are smaller and have much smaller nuclei than their neighbouring wild-type cells in mosaic egg chambers. Homozygous follicle cell clones fail to undergo the switch from mitotic cycles to endocycles, with mitotic markers present after stage 6. This proliferation phenotype is more pronounced in the posterior follicle cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

CoRest[+]/CoRestGF60 is an enhancer of visible | dominant phenotype of Dl7

Other
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

CoRest[+]/CoRestGF60 is an enhancer of wing vein phenotype of Dl7

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The wing defects seen in Dl7/+ flies are enhanced by CoRestGF60/+: the extent of thickening and deltas at the wing veins is increased and in some cases severe wing blistering is seen.

CoRestGF60/NXK11 transheterozygotes show thickened wing veins and deltas. Wing blistering is occasionally seen.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)