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General Information
Symbol
Dmel\HcfHR1
Species
D. melanogaster
Name
FlyBase ID
FBal0267506
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Hcf sequence extending from -344 to +4004 relative to the transcription start site has been replaced by a w+mW.hs marker flanked by loxP sites.
Insertion components
TI{TI}HcfHR1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
A significant proportion of HcfHR1 homozygous adults show ectopic wing veins and ectopic scutellar bristles, as compared to controls.
Homozygotes survive until the pupal stage, where they show approximately 50% lethality. Of those animals surviving to adulthood, 30% of males and 100% of females are sterile. Homozygous pupae and adults are smaller than normal. The wings are reduced in size, at least partly because of a reduction in cell size. Homozygous wing discs show normal cell proliferation, but have increased levels of apoptosis compared to wild type. The ovaries of homozygous females are usually underdeveloped. Egg chamber degeneration at around stage 8 of oogenesis is seen. The females lay some eggs, which are often fragile and smaller than normal, and have abnormally shaped anterior termini and dorsal appendages. Homozygous adults show loss of humeral bristles (60% penetrance), held out wings (30% penetrance) and an ectopic vein initiating from the posterior crossvein in the wing (60% penetrance). Homozygous males have a reduced number of sex comb teeth (80% penetrance for 9 or fewer teeth/sex comb).
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Statement
Reference
HcfHR1 has small body | adult stage phenotype, non-enhanceable by E(z)[+]/E(z)su301
HcfHR1 has small body | adult stage phenotype, non-enhanceable by Pc1/Pc[+]
HcfHR1 has small body | adult stage phenotype, non-enhanceable by Pc3/Pc[+]
NOT suppressed by
Statement
Reference
HcfHR1 has small body | adult stage phenotype, non-suppressible by E(z)[+]/E(z)su301
HcfHR1 has small body | adult stage phenotype, non-suppressible by Pc1/Pc[+]
HcfHR1 has small body | adult stage phenotype, non-suppressible by Pc3/Pc[+]
Enhancer of
Statement
Reference
Hcf[+]/HcfHR1 is an enhancer of visible phenotype of Pc1
Hcf[+]/HcfHR1 is an enhancer of visible phenotype of Pc3
Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
HcfHR1 has wing vein | ectopic phenotype, enhanceable by skd1/skd[+]
NOT Enhanced by
Statement
Reference
HcfHR1 has humeral bristle phenotype, non-enhanceable by E(z)[+]/E(z)su301
HcfHR1 has wing vein | ectopic phenotype, non-enhanceable by E(z)[+]/E(z)su301
HcfHR1 has humeral bristle phenotype, non-enhanceable by Pc1/Pc[+]
HcfHR1 has sex comb phenotype, non-enhanceable by Pc1/Pc[+]
HcfHR1 has humeral bristle phenotype, non-enhanceable by Pc3/Pc[+]
HcfHR1 has sex comb phenotype, non-enhanceable by Pc3/Pc[+]
Suppressed by
Statement
Reference
HcfHR1 has wing vein | ectopic phenotype, suppressible by Pc1/Pc[+]
HcfHR1 has wing vein | ectopic phenotype, suppressible by Pc3/Pc[+]
NOT suppressed by
Statement
Reference
HcfHR1 has humeral bristle phenotype, non-suppressible by Pc1/Pc[+]
HcfHR1 has sex comb phenotype, non-suppressible by Pc1/Pc[+]
HcfHR1 has humeral bristle phenotype, non-suppressible by Pc3/Pc[+]
HcfHR1 has sex comb phenotype, non-suppressible by Pc3/Pc[+]
HcfHR1 has humeral bristle phenotype, non-suppressible by E(z)[+]/E(z)su301
HcfHR1 has wing vein | ectopic phenotype, non-suppressible by E(z)[+]/E(z)su301
Enhancer of
Statement
Reference
HcfHR1/HcfHR1 is an enhancer of wing vein | ectopic phenotype of sxcH537A
Hcf[+]/HcfHR1 is an enhancer of mesothoracic preepisternum phenotype of Pc1
Hcf[+]/HcfHR1 is an enhancer of mesothoracic preepisternum phenotype of Pc3
Other
Additional Comments
Genetic Interactions
Statement
Reference
sxcH537A, HcfHR1 double homozygous adults show a more prevalent ectopic wing vein phenotype than either single homozygotes and a more prevalent ectopic scutellar bristle phenotype than the HcfHR1 single homozygotes.
HcfHR1 shows leg defects when in double heterozygous combination with brm1 (20% penetrance), brm20 (10% penetrance) or mor1 (10% penetrance). HcfHR1/+ enhances the penetrance of the T2 to T1 transformation (reduction of the sternopleural region) seen in Pc1/+ and Pc3/+ flies, from 3% to 60% and from 3% to 40% respectively. The adult size and humeral bristle phenotypes of HcfHR1 mutants are not affected by Pc1/+, Pc3/+ or E(z)su301/+. The reduced sex comb phenotype of HcfHR1 is not modified by Pc1/+ or Pc3/+. The ectopic vein phenotype of HcfHR1 mutants is suppressed by Pc1/+ and by Pc3/+, whereas it is unaffected by E(z)su301/+. 3% of Pc1/+ ; HcfHR1 males, 4% of Pc3/+ ; HcfHR1 males and 2% of AsxXF23/+ ; HcfHR1 males have defects in rotation of the genitalia. 30% of skd1/+ ; HcfHR1 males have defects in rotation of the genitalia. 30% of skd1/+ ; HcfHR1 flies have extra scutellar bristles. The expressivity of the ectopic wing vein phenotype seen in HcfHR1 mutants is increased by skd1/+.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Expression of HcfScer\UAS.T:Uuuu\T7,T:Zzzz\FLAG under the control of Scer\GAL4Act.PU at 18[o]C rescues the reduced body size, loss of humeral bristles, held-out wings and ectopic veins seen in HcfHR1 animals.
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)