Allele Dmel\PGRP-LC^{A.EC.Scer\UAS}

General Information
Symbol	Dmel\PGRP-LC^{A.EC.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0267516
Feature type	allele	Associated gene	Dmel\PGRP-LC

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - deletion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - deletion (Maillet et al., 2008) in vitro construct - regulatory fusion (Maillet et al., 2008)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of the extracellular domain of the PGRP-LC A isoform. (Maillet et al., 2008)
Carried in construct	P{UAS-PGRP-LC.A.EC} (Maillet et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	immune response defective \| adult stage, with Scer\GAL4^yolk (Maillet et al., 2008) immune response defective \| larval stage, with Scer\GAL4^hs.PB (Maillet et al., 2008)
Phenotype Manifest In

Detailed Description
	Statement Reference PGRP-LC[A.EC.Scer\UAS] is unable to activate the IMD pathway when expressed in the adult fat body under the control of Scer\GAL4[yolk], or in the larval fat body under the control of Scer\GAL4[hs.PB]. (Maillet et al., 2008)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to rescue	Scer\GAL4^yolk/PGRP-LC^{A.EC.Scer\UAS} fails to rescue PGRP-LC^ΔE/PGRP-LC^ΔE (Maillet et al., 2008)
Comments	Expression of PGRP-LC[A.EC.Scer\UAS] under the control of Scer\GAL4[yolk] does not rescue the susceptibility of PGRP-LC[ΔE] mutants to infection by Gram-negative bacteria. (Maillet et al., 2008)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	PGRP-LC^{A.EC.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Maillet et al., 2008, Cell Host Microbe 3(5): 293--303 The Drosophila peptidoglycan recognition protein PGRP-LF blocks PGRP-LC and IMD/JNK pathway activation. [FBrf0204914]

Allele Dmel\PGRP-LCA.EC.Scer\UAS

Allele Dmel\PGRP-LC^{A.EC.Scer\UAS}