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General Information
Symbol
Dmel\kugN103-2
Species
D. melanogaster
Name
FlyBase ID
FBal0267777
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
fat2N103-2
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Complex lesion leading to a premature stop codon at position 3718.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

In kugN103-2 mutants, follicular epithelium migration is blocked; kugN103-2 heterozygous eggs are slightly but significantly rounder than controls.

kugN103-2 mutant follicular epithelia fail to undergo migration, in contrast to controls.

kugN103-2 mutant cells in mosaic follicular epithelia exhibit a non-cell-autonomous defect in leading edge protrusion formation, as wild type cells positioned directly behind kugN103-2 mutant cells lack protrusions, whereas kugN103-2 cells positioned directly behind wild type cells form protrusions normally. When a cell's leading edge contacts both a kugN103-2 cell and a wild type cell, protrusions are lost only from the region contacting the kugN103-2 cell. kugN103-2 mutant cells also exhibit significantly elongated basal surfaces, indicative of a defect in trailing edge retraction.

Follicle cell epithelia fail to migrate in mutant females.

Females carrying homozygous follicle cell clones produce round eggs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhancer of
Statement
Reference

kugN103-2/kug[+] is a non-enhancer of abnormal size | oogenesis | oogenesis phenotype of Sema5cK175

kugN103-2/kug[+] is a non-enhancer of visible | oogenesis phenotype of Sema5cK175

Phenotype Manifest In
Enhanced by
Statement
Reference

kugN103-2 has egg phenotype, enhanceable by Sema5cK175/Sema5cK175

NOT Enhancer of
Statement
Reference

kugN103-2/kug[+] is a non-enhancer of egg phenotype of Sema5cK175

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)