Allele Dmel\AP-1μ^NIG.9388R

General Information
Symbol	Dmel\AP-1μ^NIG.9388R	Species	D. melanogaster
Name		FlyBase ID	FBal0267842
Feature type	allele	Associated gene	Dmel\AP-1μ

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - RNAi
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Kametaka et al., 2012) in vitro construct - RNAi (Kametaka et al., 2012)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS drives expression of a AP-47 RNAi construct. (Kametaka et al., 2012)
Carried in construct	P{NIG.9388R} (Kametaka et al., 2012)
Associated Sequence Features	dsRNA-9388R
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| pupal stage, with Scer\GAL4^Act.PU (Kametaka et al., 2012) partially lethal - majority die, with Scer\GAL4^ey.PU (Kametaka et al., 2012)
Phenotype Manifest In
	eye, with Scer\GAL4^ey.PU (Kametaka et al., 2012) ommatidium, with Scer\GAL4^ey.PU (Kametaka et al., 2012)
Detailed Description
	Statement Reference Scer\GAL4[GMR.PU]-mediated expression results in a normal eye. Scer\GAL4[ey.PU]-mediated expression results in a rough eye with irregular alignment of ommatidia and bristles, as well as a significant reduction in the number of adult flies eclosing. Ommatidia are of irregular sizes with excess/fewer rhabdomeres than normal; however, each ommatidium contains normally polarized photoreceptor cells, suggesting that the phenotypes are caused by defects in photoreceptor clustering during ommatidial formation. The specification of R8 neurons is disturbed in Scer\GAL4[ey.PU], AP-1σ[NIG.5864R] third instar larval discs. (Kametaka et al., 2012)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference AP-1μ^NIG.9388R, Scer\GAL4^ey.PU has partially lethal - majority die phenotype, enhanceable by Afti^NIG.3002R, Scer\GAL4^ey.PU (Kametaka et al., 2012)
NOT Enhanced by
Statement Reference AP-1μ^NIG.9388R, Scer\GAL4^ey.PU has partially lethal - majority die phenotype, non-enhanceable by Gga^NIG.3002R, Scer\GAL4^ey.PU (Kametaka et al., 2012) AP-1μ^NIG.9388R, Scer\GAL4^ey.PU has partially lethal - majority die phenotype, non-enhanceable by Lerp^NIG.31072R, Scer\GAL4^ey.PU (Kametaka et al., 2012)
NOT suppressed by
Statement Reference AP-1μ^NIG.9388R, Scer\GAL4^ey.PU has partially lethal - majority die phenotype, non-suppressible by Gga^NIG.3002R, Scer\GAL4^ey.PU (Kametaka et al., 2012) AP-1μ^NIG.9388R, Scer\GAL4^ey.PU has partially lethal - majority die phenotype, non-suppressible by Lerp^NIG.31072R, Scer\GAL4^ey.PU (Kametaka et al., 2012)
Other
Statement Reference AP-1μ^NIG.9388R, Afti^NIG.3002R, Scer\GAL4^ey.PU has lethal \| pharate adult stage phenotype (Kametaka et al., 2012)
Phenotype Manifest In
Other
Statement Reference AP-1μ^NIG.9388R, Afti^NIG.3002R, Scer\GAL4^ey.PU has head phenotype (Kametaka et al., 2012)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of Afti[NIG.3002R] in a Scer\GAL4[ey.PU], AP-47[NIG.9388R] background results in complete loss of viable adults. These animals die at the pharate stage with loss of the head. (Kametaka et al., 2012)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	AP-1μ^NIG.9388R AP-47^NIG.9388R
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Kametaka et al., 2012, J. Cell Sci. 125(3): 634--648 AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. [FBrf0217589]

Allele Dmel\AP-1μNIG.9388R

Allele Dmel\AP-1μ^NIG.9388R