FB2025_01 , released February 20, 2025
Allele: Dmel\GstO1UAS.cKa
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General Information
Symbol
Dmel\GstO1UAS.cKa
Species
D. melanogaster
Name
FlyBase ID
FBal0267939
Feature type
allele
Associated gene
Dmel\GstO1
Associated Insertion(s)
Carried in Construct
P{UAS-GstO1.K}
Also Known As
UAS-GstO1
Key Links
Transgenic product class
wild_type
(Kim et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kim et al., 2012)
Mutagen
in vitro construct
(Kim et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-GstO1.K}
Cytology
Description

UASt regulatory sequences drive expression of GstO1 coding sequences.

(Kim et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
GstO1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  alcohol use disorder
      CEA
      (Choi et al., 2019)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  amyotrophic lateral sclerosis type 6
      modeled by Hsap\FUSUAS.cUa
      (Cha et al., 2022)
      ameliorates  Parkinson's disease
      modeled by park1
      (Kim et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adults expressing GstO1UAS.cKa under the control of Scer\GAL4da.PU are significantly more resistant to ethanol sedation than controls: individuals stop climbing and succumb to sedation (loss of postural control) later than controls.

      (Choi et al., 2019)

      Expression of GstO1UAS.cKa under the control of Scer\GAL4VGlut-OK371 does not affect mitochondrial number or mitochondrial length in axons of adult neurons, compared to controls.

      (Smith et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      GstO1UAS.cKa/Scer\GAL4how-24B is a non-suppressor of wing phenotype of park1

      (Kim et al., 2012)

      GstO1UAS.cKa/Scer\GAL4how-24B is a non-suppressor of adult thorax phenotype of park1

      (Kim et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of GstO1Scer\UAS.cKa under the control of Scer\GAL4phm.PO does not rescue the embryonic lethality associated with homozygous GstE14KO mutants.

      (Enya et al., 2014)

      Expression of GstO1Scer\UAS.cKa using the muscle-specific driver Scer\GAL4how-24B does not affect either of the thorax and downturned wing phenotypes found in park1 mutants.

      (Kim et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CG6662Scer\UAS.cKa
      GstO1Scer\UAS.cKa
      GstO1UAS.cKa
      Name Synonyms
      Secondary FlyBase IDs
        References (5)