FB2022_03, released June 9, 2022

Allele: Dmel\BruceE23

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General Information
Symbol
Dmel\BruceE23
Species
D. melanogaster
Name
FlyBase ID
FBal0268096
Feature type
allele
Associated gene
Dmel\Bruce
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
         
        Progenitor genotype
        Cytology
        Nature of the lesion
        Statement
        Reference

        BruceE23 contains an 11bp deletion in the coding sequence, generating a frameshift at amino acid residue 3901, leading to a premature stop codon at amino acid residue 3906. This results in truncation of the protein prior to the UBC domain.

        (Domingues and Ryoo, 2012)
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Enhancer of
        Statement
        Reference

        Bruce[+]/BruceE23 is an enhancer of eye phenotype of rprGMR.PD

        (Domingues and Ryoo, 2012)
        NOT Enhancer of
        NOT Suppressor of
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        A BruceE23 heterozygous background dominantly enhances the rprGMR.PD eye ablation phenotype.

        A BruceE23 heterozygous background does not affect the pigment cell death phenotype caused by the overexpression of Ncpro.Scer\UAS in the developing eye under the control of Scer\GAL4GMR.PF.

        A BruceE23/+ heterozygous background has no effect on the eye ablation phenotype found upon co-expression of ArkScer\UAS.T:Zzzz\His6,T:Hsap\MYC and Ncpro.Scer\UAS in the developing eye under the control of Scer\GAL4GMR.PF.

        (Domingues and Ryoo, 2012)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        BruceE23
        dBruceE23
        (Domingues and Ryoo, 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)