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General Information
Symbol
Dmel\ZwUAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Legan
FlyBase ID
FBal0268136
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-G6PD
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a 2074bp Zw cDNA fragment.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

After 48 hours of exposure, flies expressing ZwScer\UAS.cLa under the control of Scer\GAL4elav-C155 are more tolerant to hydrogen peroxide than wild-type flies.

Expression of ZwScer\UAS.cLa under the control of either Scer\GAL4arm.PS, Scer\GAL4tub.PU, Scer\GAL4da.G32, Scer\GAL4D42 or Scer\GAL4Appl.G1a results in an increase in lifespan compared to controls.

Flies expressing ZwScer\UAS.cLa under the control of Scer\GAL4arm.PS show increased resistance to hyperoxia (100% O[[2]]) compared to controls.

Expression of ZwScer\UAS.cLa under the control of either Scer\GAL4arm.PS or Scer\GAL4Appl.G1a show increased resistance to paraquat compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Suppressor of
Statement
Reference

Scer\GAL4NP0001/ZwUAS.cLa is a suppressor of increased mortality | adult stage | conditional phenotype of Traf-likeΔ

NOT Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of ZwScer\UAS.cLa significantly improves the survival of flies expressing Scer\GAL4elav-C155>ND-23KK102085.

Co-expression of ZwScer\UAS.cLa significantly improves the survival of flies expressing Scer\GAL4elav-C155>l(1)G0334GD12103.

Xenogenetic Interactions
Statement
Reference

Overexpression of ZwScer\UAS.cLa significantly extends lifespan and suppresses eye photoreceptor neurodegeneration in flies expressing Scer\GAL4elav-C155>Hsap\HTTQ93.ex1p.Scer\UAS.

Overexpression of ZwScer\UAS.cLa does not statistically change the survival of flies co-expressing Hsap\SLC2A3Scer\UAS.cBa and Hsap\HTTQ93.ex1p.Scer\UAS using Scer\GAL4elav-C155.

12 day-old flies co-expressing Hsap\HTTQ93.ex1p.Scer\UAS and ZwScer\UAS.cLa under the control of Scer\GAL4elav-C155 display a significantly enhanced resistance to oxidative stress compared with wild-type.

Co-expression of two copies of ZwScer\UAS.cLa can partially rescue the rough eye phenotype caused by expression of Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PF.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
ZwScer\UAS.cLa
ZwUAS.cLa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Legan
Secondary FlyBase IDs
    References (8)