Allele Dmel\Lhr^T:Ivir\HA1

General Information
Symbol	Dmel\Lhr^T:Ivir\HA1	Species	D. melanogaster
Name		FlyBase ID	FBal0268225
Feature type	allele	Associated gene	Dmel\Lhr

Allele class
Mutagen	in vitro construct - coding region fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Maheshwari and Barbash, 2012)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	Lhr^+t4.8 (Maheshwari and Barbash, 2012)
Nature of the lesion	Statement Reference Three copies of the T:Ivir\HA1 tag have been inserted at the C-terminal end of the Lhr coding region. (Maheshwari and Barbash, 2012)
Carried in construct	M{mel-Lhr-HA} (Maheshwari and Barbash, 2012, Maheshwari and Barbash, 2012) P{mel-Lhr-HA} (Maheshwari and Barbash, 2012) P{ΔBap55.mel-Lhr-HA} (Maheshwari and Barbash, 2012)
Tagged with	T:Ivir\HA1 (Maheshwari and Barbash, 2012)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference Lhr[T:Ivir\HA1] fully complements Dsim\Lhr[1], which is observed as hybrid male inviability in the progeny of a cross of D. melanogaster females carrying Lhr[T:Ivir\HA1] to D. simulans Dsim\Lhr[1] males. Lhr[T:Ivir\HA1] has little effect on the viability of hybrid Hmr[Df] males (progeny of Hmr[Df] Lhr[T:Ivir\HA1] D. melanogaster females mated to either D. simulans or D. mauritiana males). Lhr[T:Ivir\HA1] reduces the viability of hybrid Hmr[1] males (progeny of Hmr[1] Lhr[T:Ivir\HA1] D. melanogaster females mated to either D. simulans or D. mauritiana males). (Maheshwari and Barbash, 2012) Hybrid Hmr[1] males (progeny of Hmr[1] Lhr[T:Ivir\HA1] D. melanogaster females mated to D. mauritiana males) carrying Lhr[T:Ivir\HA1] show 32-44% viability at room temperature and 52-69% viability at 18[o]C (compared to hybrid Hmr[1] males not carrying Lhr[T:Ivir\HA1]). (Maheshwari and Barbash, 2012)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Lhr^T:Ivir\HA1
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Maheshwari and Barbash, 2012, PLoS Genet. 8(3): e1002597 Cis-by-Trans Regulatory Divergence Causes the Asymmetric Lethal Effects of an Ancestral Hybrid Incompatibility Gene. [FBrf0217900] Maheshwari and Barbash, 2012, Genetics 192(2): 683--691 An indel polymorphism in the hybrid incompatibility gene lethal hybrid rescue of Drosophila is functionally relevant. [FBrf0219506]

Allele Dmel\LhrT:Ivir\HA1

Allele Dmel\Lhr^T:Ivir\HA1