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General Information
Symbol
Dmel\Egfr::Hsap\EGFRhE-E.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0268318
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of the extracellular and transmembrane domains of Hsap\EGFR fused to the intracellular domain of Egfr. The protein is tagged at the C-terminal end with GFP.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Co-expression of Hsap\TGFAScer\UAS.T:Ivir\HA1 and Egfr::Hsap\EGFRhE-E.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4slbo.2.6 results in strong defects in border cell migration, with no migration being seen in over 70% of stage 10 egg chambers.

The effect on border cell cluster migration when all border cells co-express PvrDN.Scer\UAS and EgfrDN.Scer\UAS under the control of Scer\GAL4slbo.2.6 and a single border cell expresses Egfr::Hsap\EGFRhE-E.Scer\UAS.T:Avic\GFP have been studied. In those border cell clusters where the single Egfr::Hsap\EGFRhE-E.Scer\UAS.T:Avic\GFP-expressing cell is located at the front of the cluster, the cluster on average moves forward, when the Egfr::Hsap\EGFRhE-E.Scer\UAS.T:Avic\GFP-expressing cell is in the back, the cluster on average moves relatively more backwards.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Egfr::Hsap\EGFRhE-E.Scer\UAS.T:Avic\GFP
Egfr::Hsap\EGFRhE-E.UAS.GFP
Name Synonyms
Secondary FlyBase IDs
    References (2)