|Feature type||allele||Associated gene||Dmel\dysc|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by insertion|
|Phenotype Manifest In|
dysc[s168] homozygotes display arrhythmic locomotor patterns in constant dark conditions, with a minority showing weak rhythmicity. In contrast, the eclosion rhythm of these flies closely mirrors wild type controls. dysc[s168]/Df(3L)BSC614 animals display arrhythmic locomotor patterns in constant dark conditions. In contrast to wild type flies, dysc[s168] homozygotes do not exhibit anticipation of lights-on in 12 h light:dark conditions, while anticipation of lights-off is maintained. Overall daytime and nighttime activity is greater in these mutants compared to wild type in these conditions. dysc[s168]/dysc[c03838] and dysc[s168]/dysc[c05107] animals display arrhythmic locomotor patterns in constant dark conditions. Compared to wild type, dysc[s168] mutant Ilp2-positive neurons in adult brains show a much greater reduction in the outward current when the membrane potential is held at -30 mV, indicating a loss of non-activating currents. In contrast to wild type, the non-activating currents in dysc[s168] mutant Ilp2-positive neurons exhibit only a slight increase upon addition of CaCl[]. Whereas application of 1 mM tetrathylammonium (a blocker of slo channels) reduces the total outward current by 63% in wild type neurons, it produces only a 17% reduction in dysc[s168] neurons.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Not rescued by|
Scer\GAL4[elav.PU]-, Scer\GAL4[dysc.PJ]-, or Scer\GAL4[C164]-mediated expression of dysc[Scer\UAS.g] rescues the locomotor rhythm defects of dysc[c03838]/dysc[s168] animals. Scer\GAL4[elav.PU]-mediated expression of dysc[Scer\UAS.f] does not rescue the locomotor rhythm defects of dysc[c03838]/dysc[s168] animals.
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 1 )|