FlyBase Allele Report: Hsap\ADARB1[UAS.cKa]

General Information

Symbol

Hsap\ADARB1^UAS.cKa

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct of Keegan

FlyBase ID

FBal0268555

Feature type

allele

Associated gene

Hsap\ADARB1

Associated Insertion(s)

Carried in Construct

P{UAS-hADAR2.K}

Also Known As

UAS-hADAR2

Key Links

Transgenic product class

cDNA

(Keegan et al., 2011)

wild_type

(Keegan et al., 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Keegan et al., 2011)

wild_type

(Keegan et al., 2011)

Mutagen

in vitro construct

(Keegan et al., 2011)

Progenitor genotype

Carried in construct

P{UAS-hADAR2.K}

Cytology

Description

UAS regulatory sequences drive expression of a full-length Hsap\ADARB1 cDNA.

(Keegan et al., 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\ADARB1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^ChAT.7.4/Hsap\ADARB1^UAS.cKa is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Adar^E374A

(Deng et al., 2020)

Scer\GAL4^ChAT.7.4/Hsap\ADARB1^UAS.cKa is a suppressor of abnormal locomotor behavior | adult stage phenotype of Adar^5G1

(Keegan et al., 2011)

Scer\GAL4^ChAT.7.4/Hsap\ADARB1^UAS.cKa is a suppressor of abnormal neuroanatomy | adult stage | conditional phenotype of Adar^5G1

(Keegan et al., 2011)

Scer\GAL4^ChAT.7.4/Hsap\ADARB1^UAS.cKa is a suppressor of abnormal locomotor behavior | adult stage phenotype of Adar^1F4

(Keegan et al., 2011)

Other

Statement

Reference

Adar^E374A, Adar^GD1355, Hsap\ADARB1^UAS.cKa, Scer\GAL4^ChAT.7.4 has abnormal locomotor behavior | adult stage phenotype

(Deng et al., 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^ChAT.7.4/Hsap\ADARB1^UAS.cKa is a suppressor of retina | conditional phenotype of Adar^5G1

(Keegan et al., 2011)

Scer\GAL4^ChAT.7.4/Hsap\ADARB1^UAS.cKa is a suppressor of adult mushroom body | conditional phenotype of Adar^5G1

(Keegan et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\ADARB1^Scer\UAS.cKa under the control of Scer\GAL4^Cha.7.4 significantly suppresses the neurodegeneration phenotype seen in the mushroom body calyces and retina of 30 day old Adar^5G1 adults.

(Keegan et al., 2011)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\ADARB1^Scer\UAS.cKa

Hsap\ADARB1^UAS.cKa

Name Synonyms

Saccharomyces cerevisiae UAS construct of Keegan

Secondary FlyBase IDs

References (2)

Report Sections

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