Allele Dmel\pros^IG2227

General Information
Symbol	Dmel\pros^IG2227	Species	D. melanogaster
Name		FlyBase ID	FBal0268589
Feature type	allele	Associated gene	Dmel\pros

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Hartl et al., 2011)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: L850R. (Hartl et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective \| adult stage \| somatic clone (Hartl et al., 2011)
Phenotype Manifest In
	carbon dioxide sensitive neuron \| ectopic \| somatic clone (Hartl et al., 2011)
Detailed Description
	Statement Reference Homozygous clones induced by the eyFLP method result in ectopic CO[[2]] neurons on the maxillary palp (MP). The ectopic neurons show dual targeting specificity: in addition to targeting the V-glomerulus they also innervate a set of medial glomeruli normally innervated by two MP olfactory receptor neuron classes. The ectopic neurons are functional and respond to CO[[2]]. The number of antennal CO[[2]] neurons is unaffected. (Hartl et al., 2011)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference pros^IG2227 has neuroanatomy defective \| somatic clone \| adult stage phenotype, suppressible \| partially \| somatic clone by esg[+]/esg^k00606 (Hartl et al., 2011) pros^IG2227 has neuroanatomy defective \| somatic clone \| adult stage phenotype, suppressible \| partially \| somatic clone by mir-279^{Scer\UAS.T:Disc\RFP}/Scer\GAL4^Act.PU (Hartl et al., 2011) pros^IG2227 has neuroanatomy defective \| somatic clone \| adult stage phenotype, suppressible \| partially \| somatic clone by nerfin-1¹⁵⁹/nerfin-1[+] (Hartl et al., 2011)
NOT suppressed by
Statement Reference pros^IG2227 has neuroanatomy defective \| somatic clone \| adult stage phenotype, non-suppressible \| somatic clone by exex[+]/exex^KK30 (Hartl et al., 2011)
Phenotype Manifest In
Suppressed by
Statement Reference pros^IG2227 has carbon dioxide sensitive neuron \| ectopic \| somatic clone phenotype, suppressible \| partially \| somatic clone by esg[+]/esg^k00606 (Hartl et al., 2011) pros^IG2227 has carbon dioxide sensitive neuron \| ectopic \| somatic clone phenotype, suppressible \| partially \| somatic clone by mir-279^{Scer\UAS.T:Disc\RFP}/Scer\GAL4^Act.PU (Hartl et al., 2011) pros^IG2227 has carbon dioxide sensitive neuron \| ectopic \| somatic clone phenotype, suppressible \| partially \| somatic clone by nerfin-1¹⁵⁹/nerfin-1[+] (Hartl et al., 2011)
NOT suppressed by
Statement Reference pros^IG2227 has carbon dioxide sensitive neuron \| ectopic \| somatic clone phenotype, non-suppressible \| somatic clone by exex[+]/exex^KK30 (Hartl et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference Expression of mir-279[Scer\UAS.T:Disc\RFP] under the control of Scer\GAL4[Act.PU] suppresses the formation of ectopic CO[[2]] neurons on the maxillary palp caused by pros[IG2227] clones in 80% of animals. The number of ectopic CO[[2]] neurons on the maxillary palp in animals containing pros[IG2227] clones is significantly suppressed if they are also carrying either esg[k00606]/+ or nerfin-1[159]/+, but is unaffected if they are also carrying exex[KK30]/+. (Hartl et al., 2011)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	pros^IG2227 is rescued by Scer\GAL4^Act.PU/pros^Scer\UAS.cMa (Hartl et al., 2011)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	pros^IG2227 (Hartl et al., 2011)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Hartl et al., 2011, J. Neurosci. 31(44): 15660--15673 A New Prospero and microRNA-279 Pathway Restricts CO2 Receptor Neuron Formation. [FBrf0216631]

Allele Dmel\prosIG2227

Allele Dmel\pros^IG2227