FB2025_01 , released February 20, 2025
Allele: Dmel\Zip42C.1UAS.cLa
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General Information
Symbol
Dmel\Zip42C.1UAS.cLa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Lang
FlyBase ID
FBal0268611
Feature type
allele
Associated gene
Dmel\Zip42C.1
Associated Insertion(s)
Carried in Construct
P{UAS-ZIP1.L}
Key Links
Transgenic product class
genomic_DNA
(Lang et al., 2012)
wild_type
(Lang et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Lang et al., 2012)
wild_type
(Lang et al., 2012)
Mutagen
in vitro construct
(Lang et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-ZIP1.L}
Cytology
Description

UAS sequences drive expression of Zip42C.1 genomic DNA.

(Lang et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Zip42C.1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Alzheimer's disease
      modeled by Hsap\APPAβ42.UAS.Tag:SS(rPENK)
      (Lang et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      No obvious eye phenotypes are seen when Zip42C.1Scer\UAS.cLa is expressed under the control of Scer\GAL4elav.PU.

      (Huang et al., 2014)

      Flies expressing ZIP1Scer\UAS.cLa ubiquitously under the control of Scer\GAL4Act5C.PI are more sensitive to zinc overdose than controls.

      The amount of vacuolisation seen in the brains of 20 day old flies expressing ZIP1Scer\UAS.cLa under the control of Scer\GAL4elav.PLu is similar to controls.

      Flies expressing ZIP1Scer\UAS.cLa under the control of Scer\GAL4elav.PLu develop locomotor defects with age; from 30 days onwards a significantly greater proportion of flies display defects in climbing ability compared to controls. Lifespan is reduced by approximately 7% compared to controls.

      Expressing ZIP1Scer\UAS.cLa under the control of Scer\GAL4elav.PLu has no effect on the memory of 5 day old flies following olfactory aversive conditioning.

      (Lang et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Zip42C.1Scer\UAS.cLa enhances the rough eye phenotype seen in flies expressing Hsap\MAPTR406W.Scer\UAS under the control of Scer\GAL4elav.PU. Lifespan is also further shortened. The level of vacuolisation in the CNS is exacerbated.

      (Huang et al., 2014)

      Expression of ZIP1Scer\UAS.cLa enhances the brain vacuolisation phenotype seen in 20 day old flies when Hsap\APPAβ1-42.Scer\UAS.cIa is expressed under the control of Scer\GAL4elav.PLu.

      Expression of ZIP1Scer\UAS.cLa enhances the locomotor defects seen when Hsap\APPAβ1-42.Scer\UAS.cIa is expressed under the control of Scer\GAL4elav.PLu. Flies begin to display climbing defects at around 15 days after eclosion, as opposed to 20-25 days when Hsap\APPAβ1-42.Scer\UAS.cIa is expressed alone.

      Expression of ZIP1Scer\UAS.cLa enhances the reduction in lifespan seen when Hsap\APPAβ1-42.Scer\UAS.cIa is expressed under the control of Scer\GAL4elav.PLu. Median lifespan is reduced by 12.5% and 22.2% at 25[o]C and 29[o]C respectively.

      Expression of ZIP1Scer\UAS.cLa suppresses the memory loss seen in 5 day old flies when Hsap\APPAβ1-42.Scer\UAS.cIa is expressed under the control of Scer\GAL4elav.PLu.

      (Lang et al., 2012)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      ZIP1Scer\UAS.cLa
      Zip42C.1Scer\UAS.cLa
      Zip42C.1UAS.cLa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Lang
      Secondary FlyBase IDs
        References (3)