FB2025_05 , released December 11, 2025
Allele: Dmel\Syx7brd1615
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General Information
Symbol
Dmel\Syx7brd1615
Species
D. melanogaster
Name
FlyBase ID
FBal0268621
Feature type
allele
Associated gene
Dmel\Syx7
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ghabrial et al., 2011)
Progenitor genotype
Cytology
Description

Amino acid replacement: ?154term.

(Schottenfeld-Roames et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:21,447,204..21,447,204 [+]
Nucleotide change:

C21447204T

Amino acid change:

Q154term | Syx7-PA; Q154term | Syx7-PB

Reported amino acid change:

?154term

Comment:

The mutation results in a truncated Syx7 protein of 153 amino acids. Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Schottenfeld-Roames et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Terminal tracheal cells mutant for Syx7brd1615 display branching and lumen defects. Early endosomes are largely absent from Syx7brd1615 mutant terminal cells.

      (Schottenfeld-Roames et al., 2014)

      Syx7brd1615 mutants exhibit a variable tracheal terminal cell multi-convoluted lumen defect. They exhibit a moderate pruning defect.

      (Ghabrial et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Syx7brd1615 has terminal tracheal cell | somatic clone phenotype, suppressible by MoeG0323/Moe[+]

      (Schottenfeld-Roames et al., 2014)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Terminal tracheal cells that are homozygous mutant for both crb11A22 and Syx7brd1615 are almost completely rescued for cysts, although, defects in branch number are enhanced as compared to Syx7brd1615 alone.

      Heterozygosity for MoeG0323 dramatically rescues the Syx7brd1615 terminal tracheal cell defects. The number of cysts is reduced, and terminal branching is greatly restored. The early endocytosis defects of Syx7brd1615 are not rescued by heterozygous MoeG0323.

      (Schottenfeld-Roames et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      1615
      (Ghabrial et al., 2011)
      Syx7brd1615
      (Schottenfeld-Roames et al., 2014)
      braided1615
      Name Synonyms
      braided1615
      (Schottenfeld-Roames et al., 2014)
      Secondary FlyBase IDs
        References (2)