Allele Dmel\TSG101⁹⁴²

General Information
Symbol	Dmel\TSG101⁹⁴²	Species	D. melanogaster
Name		FlyBase ID	FBal0268623
Feature type	allele	Associated gene	Dmel\TSG101

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Ghabrial et al., 2011)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: P86L. (Ghabrial et al., 2011) Nucleotide substitution: C?T. (Ghabrial et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	embryonic/larval tracheal system (Ghabrial et al., 2011) eye \| somatic clone (Ghabrial et al., 2011) terminal tracheal cell (Ghabrial et al., 2011)
Detailed Description
	Statement Reference TSG101[942] mutant trachea exhibit selective terminal cell pruning. They ramify much less extensively than in wild-type, but the branching defect appears selective for side branches and possibly other later rounds of terminal branching. These mutants also exhibit a terminal cell gas-filling defect that typically affects only new or distal portions of sub-cellular tubes. The tip-clearance defects are variable, with some mutant termina cells more severely affected than others, even within the same mosaic animal. TSG101[942] mutant eye cell clones fail to rescue eye development in an EGUF/hid eye assay (where forced expression of a cell death gene in the eye imaginal disc eliminates wild-type cells, leaving the adult eyes to develop almost entirely from clones of homozygous mutant cells), resulting in adults lacking eyes or with grossly undersized eyes. (Ghabrial et al., 2011)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	942 (Ghabrial et al., 2011) TSG101⁹⁴²
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087 A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368]

Allele Dmel\TSG101942

Allele Dmel\TSG101⁹⁴²