FB2025_01 , released February 20, 2025
Allele: Dmel\numbS2D.UAS
Open Close
General Information
Symbol
Dmel\numbS2D.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0268713
Feature type
allele
Associated gene
Dmel\numb
Associated Insertion(s)
Carried in Construct
P{UAS-numb.S2D}
Also Known As
Numb-S2D
Key Links
Transgenic product class
missense_variant
(Ouyang et al., 2011)
polypeptide_post_translational_processing_variant
(Ouyang et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Ouyang et al., 2011)
polypeptide_post_translational_processing_variant
(Ouyang et al., 2011)
Mutagen
in vitro construct
(Ouyang et al., 2011)
Progenitor genotype
Carried in construct
P{UAS-numb.S2D}
Cytology
Description

UAS regulatory sequences drive expression of numb sequences where two putative phospho-sites (S183 and S188) have been mutated to be phosphomimetic (i.e. appear always phosphorylated).

(Ouyang et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
numb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of numbS2D.Scer\UAS in larval brain neuroblasts under the control of Scer\GAL4insc-Mz1407 leads to a significant increase in type II neuroblast number.

      (Ouyang et al., 2011)

      Expression of numbS2D.Scer\UAS under the control of Scer\GAL4insc-Mz1407 induces a mild supernumerary neuroblast phenotype.

      (Ouyang et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Knockdown of Nc through expression of NcdsRNA.Scer\UAS significantly augmented numbS2D.Scer\UAS induced ectopic neuroblast formation. This enhancement is not due to prevention of neuroblast apoptosis, as the total number of TUNEL[+] cells in the central brain doesn't change.

      A Nc51 heterozygous background enhances ectopic neuroblast formation due to numbS2D.Scer\UAS expression.

      (Ouyang et al., 2011)

      ?p53[-] p2.

      (Ouyang et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      numbS2D.Scer\UAS
      numbS2D.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)