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General Information
Symbol
Dmel\Octβ1R1
Species
D. melanogaster
Name
FlyBase ID
FBal0268850
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
complex substitution
Comment:

Scer\FLP1-mediated recombination between the two progenitor insertions has deleted the intervening genomic sequence (removing most of oa2 except the 5' UTR and first coding exon). A reconstituted PBac{WHr} element remains at the deletion site.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Scer\FLP1-mediated recombination between the two progenitor insertions has deleted the intervening genomic sequence (removing most of oa2 except the 5' UTR and first coding exon). A reconstituted PBac{WHr} element remains at the deletion site.

Insertion components
PBac{WHr}Octβ1R1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The number of natural synaptopods (motile filopodia-like extensions) at type II neuromuscular junctions is significantly increased in homozygous and oa21/Df(3R)Exel6191 third instar larvae compared to wild type. The number of type II boutons at the neuromuscular junction is also increased in these larvae.

In contrast to wild type, type II neuromuscular junctions do not show an increase in the number of natural synaptopods in response to octopamine in homozygous and oa21/Df(3R)Exel6191 third instar larvae. Similarly, no increase in the number of natural synaptopods in response to forskolin is seen in homozygous larvae, in contrast to wild type.

Homozygous and oa21/Df(3R)Exel6191 third instar larvae show a significant increase in the number of type I boutons at the neuromuscular junction compared to wild type.

In contrast to wild type, homozygous and oa21/Df(3R)Exel6191 larvae fail to respond to starvation by increasing locomotor speed, although these animals also have a reduced basal locomotor speed under non-starvation conditions.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Suppressor of
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

G-oα47A007/+ ; oa21/+ double heterozygous third instar larvae show a significant increase in the number of natural synaptopods (motile filopodia-like extensions) and type II boutons at the type II neuromuscular junction compared to wild type. The number of type I boutons at the neuromuscular junction is also increased in these animals.

The reduction in the number of natural synaptopods and number of type II boutons at the type II neuromuscular junction which is seen in third instar larvae expressing dncScer\UAS.cCa under the control of Scer\GAL4Tdc2.PC is not altered if the larvae are also homozygous for oa21.

The reduction in the number of natural synaptopods at the type II neuromuscular junction which is seen in rut2080 third instar larvae is not altered if the larvae are also mutant for oa21.

The number of natural synaptopods and type II boutons at the type II neuromuscular junction in Octβ2Rf05679 oa21 double mutants is significantly higher than that seen in Octβ2Rf05679 single mutants and is similar to the number in wild-type controls.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Octβ1R1
oa21
Name Synonyms
Secondary FlyBase IDs
    References (1)