FB2025_01 , released February 20, 2025
Allele: Hsap\ELP3UAS.cMa
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General Information
Symbol
Hsap\ELP3UAS.cMa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Miskiewicz
FlyBase ID
FBal0269090
Feature type
allele
Associated gene
Hsap\ELP3
Associated Insertion(s)
Carried in Construct
PBac{UAS-hELP3.M}
Also Known As
UAS-help3
Key Links
Transgenic product class
wild_type
(Miśkiewicz et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Miśkiewicz et al., 2011)
Mutagen
in vitro construct
(Miśkiewicz et al., 2011)
Progenitor genotype
Carried in construct
PBac{UAS-hELP3.M}
Cytology
Description

UAS regulatory sequences drive expression of Hsap\ELP3.

(Miśkiewicz et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\ELP3
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\ELP3Scer\UAS.cMa suppresses the larger synaptic T-bar size found upon expression of Hsap\TARDBPA315T.cMa.Scer\UAS under the control of Scer\GAL4elav.PU.

      Expression of Hsap\ELP3Scer\UAS.cMa suppresses the larger synaptic T-bar size found upon expression of Hsap\TARDBPA382T.cMa.Scer\UAS under the control of Scer\GAL4elav.PU.

      While overexpression of Hsap\ELP3Scer\UAS.cMa alone has no effect on activity or negative geotaxis, these conditions both significant suppress the activity and geotaxis defects in flies expressing Hsap\TARDBPA315T.cMa.Scer\UAS under the control of Scer\GAL4elav.PU.

      (Miskiewicz et al., 2014)

      Expression of Hsap\ELP3Scer\UAS.cMa under the control of Scer\GAL4C57, but not under the control of Scer\GAL4n-syb.PS, rescues the increased spontaneous excitatory junctional current amplitude which is seen at the neuromuscular junction in Elp3Δ3/Elp3Δ4 third instar larvae.

      (Miśkiewicz et al., 2011)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\ELP3Scer\UAS.cMa
      Hsap\ELP3UAS.cMa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Miskiewicz
      Secondary FlyBase IDs
        References (3)