FlyBase Allele Report: Dmel\Gtpx[UAS.cMa]

General Information

Symbol

Dmel\Gtpx^UAS.cMa

Species

D. melanogaster

Name

FlyBase ID

FBal0269816

Feature type

allele

Associated gene

Dmel\Gtpx

Associated Insertion(s)

Carried in Construct

P{UAS-Gtpx.M}

Also Known As

UAS-GTPx, UAS-Gtpx-1

Key Links

Transgenic product class

cDNA

(Missirlis et al., 2003)

wild_type

(Missirlis et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Missirlis et al., 2003)

wild_type

(Missirlis et al., 2003)

Mutagen

in vitro construct

(Missirlis et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-Gtpx.M}

Cytology

Description

UASt regulatory sequences drive expression of full length PHGPx cDNA.

(Missirlis et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Gtpx

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Dias-Santagata et al., 2007)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response, with Scer\GAL4^Act.PU

(Missirlis et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of PHGPx^Scer\UAS.cMa under the control of Scer\GAL4^Antp-10 does not reduce the increase in lamellocyte number seen following wasp infestation.

(Sinenko et al., 2011)

Wild type flies expressing PHGPx^Scer\UAS.cMa under the control of Scer\GAL4^Act.PU are more resistant to oxidative stress caused by paraquat treatment and hyperoxia than controls.

(Missirlis et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Gtpx^UAS.cMa has increased cell death phenotype, suppressible by Cat^UAS.cAa/Scer\GAL4^GMR.PF

(Yang et al., 2013)

Gtpx^UAS.cMa has chemical sensitive phenotype, suppressible by Cat^UAS.cAa/Scer\GAL4^GMR.PF

(Yang et al., 2013)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/Gtpx^UAS.cMa is a suppressor of increased cell death phenotype of Cat^UAS.cAa

(Yang et al., 2013)

Scer\GAL4^GMR.PF/Gtpx^UAS.cMa is a suppressor of chemical sensitive phenotype of Cat^UAS.cAa

(Yang et al., 2013)

Gtpx^UAS.cMa, Scer\GAL4^GMR.PF is a suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Yang et al., 2013)

Gtpx^UAS.cMa, Scer\GAL4^elav.PU is a suppressor of abnormal neuroanatomy | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Gtpx^UAS.cMa, Scer\GAL4^elav.PU is a suppressor of increased cell death | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

NOT Suppressor of

Statement

Reference

Scer\GAL4^hs.2sev, Cat^UAS.cAa/Gtpx^UAS.cMa is a non-suppressor of increased cell death phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^hs.2sev, Cat^UAS.cAa/Gtpx^UAS.cMa is a suppressor of eye phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

Gtpx^UAS.cMa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Yang et al., 2013)

Gtpx^UAS.cMa, Scer\GAL4^elav.PU is a suppressor of neuron | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Gtpx^UAS.cMa, Scer\GAL4^elav.PU is a suppressor of adult brain cell body rind phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Gtpx^UAS.cMa, Scer\GAL4^elav.PU is a suppressor of neuropil | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Cat^Scer\UAS.cAa and PHGPx^Scer\UAS.cMa, under the control of Scer\GAL4^GMR.PF rescues the cell death found after H[[2]]O[[2]] application on larval eye discs.

(Yang et al., 2013)

Xenogenetic Interactions

Statement

Reference

Overexpression of Cat^Scer\UAS.cAa and PHGPx^Scer\UAS.cMa in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS necrotic neurons reduces the eye defect and JNK activation without affecting primary necrosis.

(Yang et al., 2013)

Co-expression of PHGPx^Scer\UAS.cMa partially suppresses the neuron apoptosis in the cortex and neuropil of adult brains expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU.

(Dias-Santagata et al., 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Gtpx^UAS.cMa

PHGPx^Scer\UAS.cMa

PHGPx^UAS.cMa

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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