FB2025_01 , released February 20, 2025
Allele: Dmel\Fas2C.UAS
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General Information
Symbol
Dmel\Fas2C.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0269890
Feature type
allele
Associated gene
Dmel\Fas2
Associated Insertion(s)
Carried in Construct
P{UAS-Fas2.C}
Key Links
Transgenic product class
wild_type
(Beck et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Beck et al., 2012)
Mutagen
in vitro construct
(Beck et al., 2012)
Progenitor genotype
Carried in construct
P{UAS-Fas2.C}
Cytology
Description

UAS drives expression of the PC isoform of Fas2.

(Beck et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Fas2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4Rapgap1-OK6-mediated expression of Fas2C.Scer\UAS has no effect on NMJ synaptic bouton number.

      (Beck et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Fas2Scer\UAS.cLa, Fas2Scer\UAS.cLb or Fas2C.Scer\UAS in third instar larvae with GluRIICdsRNA.Scer\UAS.cBa simultaneously driven by Scer\GAL4C57 and Scer\GAL4elav-C155 does not impair homeostatic compensation at the neuromuscular junction (significant reduction in mEPSP and significant increase in quantal content compared to controls, just as is seen in larvae with expression of GluRIICdsRNA.Scer\UAS.cBa simultaneously driven by Scer\GAL4C57 and Scer\GAL4elav-C155).

      (Spring et al., 2016)

      Scer\GAL4Rapgap1-OK6-mediated expression of Fas2C.Scer\UAS does not rescue synaptic bouton number or average synaptic bouton area of beag1/Df(3R)Exel6151 animals.

      (Beck et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Scer\GAL4RapGAP1-OK6/Fas2C.UAS fails to rescue Df(1)BSC869/Fas2e76

      (Beck et al., 2012)

      Fas2C.UAS/Scer\GAL4da.G32 fails to rescue Fas2RNAi.UAS.A

      (Beck et al., 2012)
      Comments

      Scer\GAL4da.G32-mediated expression of Fas2C.Scer\UAS does not rescue the reduction in bouton number induced by Fas2dsRNA.Scer\UAS.A expression.

      Scer\GAL4Rapgap1-OK6-mediated expression of Fas2C.Scer\UAS does not rescue the reduced bouton number of Fas2e76/Df(1)BSC869 animals.

      (Beck et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fas2C.Scer\UAS
      Fas2C.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)