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General Information
Symbol
Hsap\KMT2A::Hsap\AFF1UAS.cMa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Muyrers-Chen
FlyBase ID
FBal0269993
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS regulatory sequences drive expression of a fusion protein in which the C-terminal portion of Hsap\KMT2A (including the PHD fingers and SET domain) has been replaced with amino acids 348-1211 of Hsap\AFF1.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
The pattern of BrdU incorporation is similar to wild type in the brains of larvae expressing Hsap\MLL::Hsap\AFF1Scer\UAS.cMa under the control of Scer\GAL4da.G32. Analysis of BrdU labelling indicates that the cells proceed through prophase and metaphase at a similar rate to wild type but show a delay in the later steps of mitosis. Chromatin structure appears normal in brain squashes of these larvae.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Expression of Hsap\MLL::Hsap\AFF1Scer\UAS.cMa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 fails to rescue the cuticle pattern defects seen in trxB11 homozygous embryos.
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Hsap\KMT2A::Hsap\AFF1Scer\UAS.cMa
Hsap\KMT2A::Hsap\AFF1UAS.cMa
Hsap\MLL::Hsap\AFF1Scer\UAS.cMa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Muyrers-Chen
Secondary FlyBase IDs
    References (1)