FB2025_01 , released February 20, 2025
Allele: Dmel\Cad99C51C
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General Information
Symbol
Dmel\Cad99C51C
Species
D. melanogaster
Name
FlyBase ID
FBal0270001
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Nature of the Allele
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a deletion that removes part of Cad99C, spanning from 3572bp 5' to 7174bp 3' of the translation start codon.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Comment:

Deletion resulting from the imprecise excision of P{EP}Cad99CGE23478, which removes sequences from 3572bp 5' to 7174bp 3' of the Cad99C translation start codon.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Eggs laid by homozygous females spontaneously collapse after deposition and do not develop into larvae. These eggs are nearly all permeable to the dye Neutral Red after dechorionation, suggesting a vitelline membrane defect. Ultrastructurally, the mutant vitelline membrane is of uneven thickness and occasionally has holes.

More than 80% of eggs laid by Cad99C57A/Cad99C51C and Cad99C51C/Cad99C120B females are permeable to the dye Neutral Red after dechorionation, suggesting a vitelline membrane defect. Ultrastructurally, the Cad99C57A/Cad99C51C vitelline membrane is of uneven thickness and occasionally has holes.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)