FB2025_01 , released February 20, 2025
Allele: Dmel\AP-2α::numbPTB.UAS.GFP
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General Information
Symbol
Dmel\AP-2α::numbPTB.UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0270138
Feature type
allele
Associated gene
AP-2α::numb
Associated Insertion(s)
Carried in Construct
P{UAS-AP-2α::numb.PTB.GFP}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Song and Lu, 2012)
Progenitor genotype
Carried in construct
P{UAS-AP-2α::numb.PTB.GFP}
Cytology
Description

UAS regulatory sequences drive expression of a GFP-tagged AP-2α::numb fusion protein containing numb and only the phospho-tyrosine binding (PTB) domain of AP-2α.

(Song and Lu, 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
AP-2α::numb
Tagged with
GFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of α-Adaptin::numbPTB.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4insc-Mz1407 leads to a complete depletion of type II neuroblasts.

      (Song and Lu, 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of α-Adaptin::numbPTB.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4insc-Mz1407 in a α-Adaptin06694 mutant background leads to further depletion of all type II neuroblasts.

      (Song and Lu, 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      AP-2α::numbPTB.Scer\UAS.T:Avic\GFP
      AP-2α::numbPTB.UAS.GFP
      α-Adaptin::numbPTB.Scer\UAS.T:Avic\GFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)