Allele Dmel\velo^LL05207

General Information
Symbol	Dmel\velo^LL05207	Species	D. melanogaster
Name		FlyBase ID	FBal0270270
Feature type	allele	Associated gene	Dmel\velo

Allele class
Mutagen	piggyBac transposase
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	piggyBac transposase (Berdnik et al., 2012)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference PBac{SAstopDsRed}LL05207 is inserted in the first intron of the long transcript of velo, 490bp upstream of the translational start site of the long transcript and 30bp upstream of the translational start site of the short transcript, respectively. (Berdnik et al., 2012)
Caused by insertion	PBac{SAstopDsRed}LL05207 (Berdnik et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class
	lethal (Berdnik et al., 2012) neuroanatomy defective \| somatic clone (Berdnik et al., 2012)
Phenotype Manifest In
	adult antennal lobe projection neuron DL1 adPN \| somatic clone (Berdnik et al., 2012) antennal lobe glomerulus DL1 \| somatic clone (Berdnik et al., 2012) dendrite \| somatic clone (Berdnik et al., 2012)
Detailed Description
	Statement Reference velo[LL05207] mutants exhibit projection neuron dendrite targeting defects. velo[LL05207] mutant neuroblast clones exhibit several defects. First, the number of neurons is reduced from an average of 35 ad projection neurons in wild-type to 5 neurons in velo[LL05207] mutant clones. Second, the overall dendritic mass is reduced and disorganised. Third, dendrites aberrantly innervate the wrong glomeruli within the antennal lobe, or ectopically project outside the antennal lobe. velo[LL05207] mutant DL1 projection neurons exhibit defects in axon morphology. Axons extend as wild-type and always reach the end of the lateral horn, but only form 0-2 collaterals in the mushroom body calyx, and often have a missing or shorter dorsal branch in the lateral horn. These axonal phenotypes are independent of the phenotypic class of dendrite mistargeting. (Berdnik et al., 2012)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Based on dendrite targeting defects in the antennal lobe, the following velo alleles can be ranked from most severe to weakest as follows: velo[e01260] > velo[LL05209] > velo[LL05207]. (Berdnik et al., 2012)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	velo^LL05207
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Berdnik et al., 2012, J. Neurosci. 32(24): 8331--8340 The SUMO Protease Verloren Regulates Dendrite and Axon Targeting in Olfactory Projection Neurons. [FBrf0218602]

Allele Dmel\veloLL05207

Allele Dmel\velo^LL05207