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General Information
Symbol
Dmel\Klp64DNIG.10642R
Species
D. melanogaster
Name
FlyBase ID
FBal0270549
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UASt regulatory sequences drive expression of a 500bp inverted repeat.
Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
At 18[o]C, nearly all animals expressing Klp64DNIG.10642R under the control of Scer\GAL4nub-AC-62 show mild defects in the distal part of the wings. Most of the defects seen comprise notching in the wing margin and loss of margin bristles. Phenotypes are temperature-dependent: at 29[o]C, flies can almost develop to the adult but die in the pupal case. These flies show severe shrinkage or complete loss of wing. Expressing Klp64DNIG.10642R at and near the DV boundary region using Scer\GAL4bbg-C96 causes notching along the wing margin. This phenotype is seen with 100% penetrance.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Expression of wgScer\UAS.T:Avic\GFP does not suppress the wing notching seen when Klp64DNIG.10642R is expressed under the control of Scer\GAL4bbg-C96. Expression of Klp64DNIG.10642R partially rescues the lethality seen when wgScer\UAS.T:Avic\GFP is expressed under the control of Scer\GAL4bbg-C96 at 25[o]C, resulting in the survival of 30% of adult flies with small wings. Expression of dshScer\UAS.T:Hsap\MYC does not suppress the wing notching seen when Klp64DNIG.10642R is expressed under the control of Scer\GAL4bbg-C96. Expression of armS10.Scer\UAS.T:Hsap\MYC strongly suppresses the wing notching seen when Klp64DNIG.10642R is expressed under the control of Scer\GAL4bbg-C96. The wing margin bristles are partially restored. Expression of armS2.Scer\UAS.T:Hsap\MYC does not suppress the wing notching seen when Klp64DNIG.10642R is expressed under the control of Scer\GAL4bbg-C96. Expression of armScer\UAS.Exel strongly suppresses the wing notching seen when Klp64DNIG.10642R is expressed under the control of Scer\GAL4bbg-C96. The wing margin bristles are partially restored. Heterozygous arm1 enhances the wing notching and wing hair loss seen when Klp64DNIG.10642R is expressed under the control of Scer\GAL4nub-AC-62.
Xenogenetic Interactions
Statement
Reference
Expression of Hsap\KIF3AScer\UAS.cGa strongly fully suppresses the wing notching seen when Klp64DNIG.10642R is expressed under the control of Scer\GAL4bbg-C96.
Complementation and Rescue Data
Comments
Expression of Klp64DScer\UAS.T:Ivir\HA1 rescues the wing phenotype caused by expression of Klp64DNIG.10642R under the control of Scer\GAL4Act.PU. Expression of Klp64DT114A.Scer\UAS is unable to rescue the wing phenotype seen when Klp64DNIG.10642R is expressed under the control of Scer\GAL4bbg-C96. Expression of Klp64DΔABD.Scer\UAS is unable to rescue the wing phenotype seen when Klp64DNIG.10642R is expressed under the control of Scer\GAL4bbg-C96.
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Klp64DNIG.10642R
Name Synonyms
Secondary FlyBase IDs
    References (2)