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General Information
Symbol
Dmel\ImpL2NIG.15009R
Species
D. melanogaster
Name
FlyBase ID
FBal0272063
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a 500bp inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 

ImpL2NIG.15009R ameliorates the systemic organ wasting seen when cell proliferation is induced in adult intestinal stem cells using ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5.

Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of ImpL2NIG.15009R in adult intestinal stem cells (under the control of Scer\GAL4esg-NP5130 and limited to the adult stage using Scer\GAL80ts.αTub84B) has no effect on trehalose levels.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Expression of ImpL2NIG.15009R suppresses the increase in trehalose levels seen in flies expressing ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 (under the control of Scer\GAL4esg-NP5130 and limited to the adult stage using Scer\GAL80ts.αTub84B). The overall shape of the midguts is unchanged.

The wasting of ovaries seen in flies expressing ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 (under the control of Scer\GAL4esg-NP5130 and limited to the adult stage using Scer\GAL80ts.αTub84B) is suppressed by ImpL2NIG.15009R.

The climbing defects and downturned wings seen in flies expressing ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 (under the control of Scer\GAL4esg-NP5130 and limited to the adult stage using Scer\GAL80ts.αTub84B) are suppressed by ImpL2NIG.15009R.

The mitochondrial defects seen in flies expressing ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 (under the control of Scer\GAL4esg-NP5130 and limited to the adult stage using Scer\GAL80ts.αTub84B) are suppressed by ImpL2NIG.15009R. Muscle ATP levels are also reduced.

The bloating phenotype seen in flies expressing ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 (under the control of Scer\GAL4esg-NP5130 and limited to the adult stage using Scer\GAL80ts.αTub84B) is suppressed by ImpL2NIG.15009R.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ImpL2NIG.15009R
Name Synonyms
Secondary FlyBase IDs
    References (4)