FlyBase Allele Report: Dmel\Cul1[NIG.1877R]

General Information

Symbol

Dmel\Cul1^NIG.1877R

Species

D. melanogaster

Name

FlyBase ID

FBal0272948

Feature type

allele

Associated gene

Dmel\Cul1

Associated Insertion(s)

Carried in Construct

P{NIG.1877R}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

(Japanese National Institute of Genetics, 2012.5.21)

Progenitor genotype

Carried in construct

P{NIG.1877R}

Cytology

Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-1877R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Chen et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | adult stage | progressive | nutrition conditional, with Scer\GAL4^hs.PB

(Lee et al., 2024)

Phenotype Manifest In

adult hemolymph | nutrition conditional, with Scer\GAL4^hs.PB

(Lee et al., 2024)

mechanosensory neuron of leg campaniform sensillum | increased number | nutrition conditional, with Scer\GAL4^VGlut1-OK371

(Lee et al., 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Cul1^NIG.1877R, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage | progressive phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Suppressor of

Statement

Reference

Scer\GAL4^VGlut1-OK371/Cul1^NIG.1877R is a suppressor of decreased cell number | adult stage | progressive phenotype of Uch^KO

(Lee et al., 2024)

Scer\GAL4^VGlut1-OK371/Cul1^NIG.1877R is a suppressor of abnormal sensory perception | recessive | adult stage | progressive phenotype of Uch^KO

(Lee et al., 2024)

Cul1^NIG.1877R, Scer\GAL4^VGlut1-OK371 is a suppressor of decreased cell number | adult stage | progressive phenotype of Scer\GAL4^VGlut1-OK371, sgg^A81T.UAS

(Lee et al., 2024)

Cul1^NIG.1877R, Scer\GAL4^VGlut1-OK371 is a suppressor of abnormal sensory perception | adult stage | progressive phenotype of Scer\GAL4^VGlut1-OK371, sgg^A81T.UAS

(Lee et al., 2024)

Cul1^NIG.1877R, Scer\GAL4^VGlut1-OK371 is a suppressor of decreased cell number | adult stage | progressive phenotype of Scer\GAL4^VGlut1-OK371, sna^{UAS.ORF.GW.Tag:HA}

(Lee et al., 2024)

Cul1^NIG.1877R, Scer\GAL4^VGlut1-OK371 is a suppressor of abnormal sensory perception | adult stage | progressive phenotype of Scer\GAL4^VGlut1-OK371, sna^{UAS.ORF.GW.Tag:HA}

(Lee et al., 2024)

Phenotype Manifest In

Enhancer of

Statement

Reference

Cul1^NIG.1877R, Scer\GAL4^GMR.PU is an enhancer of eye | progressive phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Suppressor of

Statement

Reference

Cul1^NIG.1877R, Scer\GAL4^VGlut1-OK371 is a suppressor of mechanosensory neuron of leg campaniform sensillum | decreased number phenotype of Scer\GAL4^VGlut1-OK371, sgg^A81T.UAS

(Lee et al., 2024)

Cul1^NIG.1877R, Scer\GAL4^VGlut1-OK371 is a suppressor of axon | adult stage phenotype of Scer\GAL4^VGlut1-OK371, sgg^A81T.UAS

(Lee et al., 2024)

Scer\GAL4^VGlut1-OK371/Cul1^NIG.1877R is a suppressor of mechanosensory neuron of leg campaniform sensillum | decreased number phenotype of Uch^KO

(Lee et al., 2024)

Scer\GAL4^VGlut1-OK371/Cul1^NIG.1877R is a suppressor of axon | adult stage phenotype of Uch^KO

(Lee et al., 2024)

Scer\GAL4^elav.PLu/Cul1^NIG.1877R is a suppressor of adult hemolymph phenotype of Uch^KO

(Lee et al., 2024)

Cul1^NIG.1877R, Scer\GAL4^hs.PB is a suppressor of adult hemolymph phenotype of Scer\GAL4^hs.PB, sgg^A81T.UAS

(Lee et al., 2024)

Cul1^NIG.1877R, Scer\GAL4^VGlut1-OK371 is a suppressor of mechanosensory neuron of leg campaniform sensillum | decreased number phenotype of Scer\GAL4^VGlut1-OK371, sna^{UAS.ORF.GW.Tag:HA}

(Lee et al., 2024)

Cul1^NIG.1877R, Scer\GAL4^VGlut1-OK371 is a suppressor of axon | adult stage phenotype of Scer\GAL4^VGlut1-OK371, sna^{UAS.ORF.GW.Tag:HA}

(Lee et al., 2024)

Cul1^NIG.1877R, Scer\GAL4^hs.PB is a suppressor of adult hemolymph phenotype of Scer\GAL4^hs.PB, sna^{UAS.ORF.GW.Tag:HA}

(Lee et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Adults co-expressing Hsap\ATXN3^{tr.Q27.UAS.Tag:HA} and Cul1^NIG.1877R under the control of Scer\GAL4^GMR.PU do not present any obvious eye defects.

(Chen et al., 2019)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

NIG-Fly

1877R-1

P{NIG.1877R}1

1877R-2

P{NIG.1877R}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cul1^NIG.1877R

lin19^NIG.1877R

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections