FB2025_01 , released February 20, 2025
Allele: Dmel\orb2Δ80Q
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General Information
Symbol
Dmel\orb2Δ80Q
Species
D. melanogaster
Name
FlyBase ID
FBal0276752
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Δ80QOrb2
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    An 80 amino acid deletion that specifically removes the glutamine rich region from the A and B isoforms of orb2.

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    orb2Δ80Q mutant flies exhibit defects in learned courtship suppression. When orb2Δ80Q male flies are repeatedly exposed to the unreceptive female they suppress courtship for less than 24hr, compared with several days in wild type.

    orb2Δ80Q mutant flies are defective in forming stable associative olfactory-reward memory. By 24 hours after training orb2Δ80Q mutant flies have a lower memory score than wild type flies.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
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    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (2)