FB2025_01 , released February 20, 2025
Allele: Dmel\pyrS3547
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General Information
Symbol
Dmel\pyrS3547
Species
D. melanogaster
Name
FlyBase ID
FBal0276774
Feature type
allele
Associated gene
Dmel\pyr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Reim et al., 2012)
Mutagen
ethyl methanesulfonate
(Schwarz et al., 2018, Reim et al., 2012)
Progenitor genotype
Cytology
Description

The splice donor site following exon 3 of pyr is mutated from GT to AT.

(Reim et al., 2012)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:11,722,775..11,722,775 [+]
Nucleotide change:

G11722775A

Comment:

The splice donor site following exon 3 of pyr is mutated from GT to AT.

(Reim et al., 2012)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      pyrS3547/Df(2R)BSC25 mutant embryos exhibit a significant decrease in the number of cardioblasts (both generic cardioblasts and ostial cardioblasts), as compared to controls.

      (Schwarz et al., 2018)

      pyrS0439/pyrS3547 embryos show a mild defect in the migration of ventral astrocytes, while the infiltration of astrocyte processes into the neuropil is not significantly different from that of controls.

      (Stork et al., 2014)

      pyrS3547 mutant stage 17 embryos show a mild reduction in the number of longitudinal visceral muscle (LVM) fibres around the midgut, particularly in the anterior portion where LVM fibre spacing is wider and the first midgut constriction is either absent or reduced.

      pyrS3547/Df(2R)BSC25 mutant stage 17 embryos show a strong reduction in the number of longitudinal visceral muscle (LVM) fibres around the midgut, particularly in the anterior portion where large areas are devoid of LVM fibres. The LVM founder cells are present at normal numbers in stage 11 embryos, but by stage 12 many of the founders have lost contact with the trunk visceral mesoderm (TVM) rather than spreading out across it. By stage 13 a large number of rounded and shrunken cells are seen some distance from the TVM.

      (Reim et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      S3547
      (Reim et al., 2012)
      pyrS3547
      (Schwarz et al., 2018, Stork et al., 2014, Reim et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)