The muscle phenotypes associated with Zzzz\CTGi480.Scer\UAS.cGa, which models human myotonic dystrophy type 1, are ameliorated by Diap1Scer\UAS.cUa in an inducible system, but in another experiment using a non-inducible driver, the reduced lifespan caused by Zzzz\CTGi480.Scer\UAS.cGa is exacerbated by Diap1Scer\UAS.cUa.
The co-expression of Diap1UAS.cUa suppresses the smaller size and the apoptosis, while enhancing the polyploidy/aneuploidy, observed in the third instar larval wing disc dorsal compartment upon the expression of pnutGD1512 from the second instar larval stage under the combined control of Scer\GAL4ap-md544 and Gal80[ts].
The triple co-expression of Diap1UAS.cUa, stgUAS.Tag:HA and pnutGD1512 from the second instar larval stage under the combined control of Scer\GAL4ap-md544 and Gal80[ts] leads to the significant enlargement of the third instar larval wing disc dorsal compartment, as compared to the Diap1UAS.cUa, pnutGD1512 double expression condition.
Expression of Diap1Scer\UAS.cUa suppresses the apoptosis seen in the wing disc when caupScer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4salm.EPv. The wing size, vein pattern and wing notching phenotypes are not modified by Diap1Scer\UAS.cUa.
Co-expression of Diap1Scer\UAS.cUa rescues the rough eye phenotype of adults, and the eye disc apoptosis and proliferation phenotype of larvae expressing OSCP1Scer\UAS.cHa under the control of Scer\GAL4GMR.PS.
Expression of Diap1Scer\UAS.cUa under the control of Scer\GAL4mGluR-NP6701 partially suppresses the short lived phenotype of mir-1000KO1/mir-1000KO2 adults and reduces the number of Caspase-3 positive cells seen in the adult brain of these flies. The climbing defects are also rescued.
Overexpression of Diap1Scer\UAS.cUa in the eye-antennal disc expressing lin-52GD12885, with both transgenes under the control of Scer\GAL4GMR.PF, suppresses the increase in apoptosis seen upon downregulation of lin-52 alone.
The co-expression of Diap1Scer\UAS.cUa does not suppress the basal delamination of cells observed upon the expression of biScer\UAS.cBa under the control of Scer\GAL4C-765 in third instar larval wing discs.
Additional expression of Diap1UAS.cUa in individuals expressing p53UAS.DΔNp53 under the control of Scer\GAL4sd.PU reduces cell death (activated caspase 3 staining), but does not prevent overgrowths in the wing pouch; these Diap1UAS.cUa and p53UAS.DΔNp53 co-expressing wing discs become smaller upon additional expression of NTRiP.cUa.
Co-expression of Diap1Scer\UAS.cUa suppresses the reduction of eye pigments and weakly suppresses the abnormal formation of ommatidia and bristles and reduced eye size seen in Scer\GAL4GMR.PS>Hsap\BCL2L13Scer\UAS.cNa flies. Co-expression of Diap1Scer\UAS.cUa in Scer\GAL4GMR.PS>Hsap\BCL2L13ΔTM.Scer\UAS flies does not result in eye phenotypes.
Co-expression of Diap1Scer\UAS.cUa partially suppresses the decreased muscle area and increased autophagy and apoptosis seen in flies expressing Zzzz\CTGi480.Scer\UAS.cGa under the control of Scer\GAL4hs.PU in response to heat shock; but enhances the shortened lifespan of flies expressing Zzzz\CTGi480.Scer\UAS.cGa under the control of Scer\GAL4Mhc.PW.
Co-expression of Diap1Scer\UAS.cUa suppresses the increased cell death induced by expression of Hsap\APLP1Scer\UAS.cMa driven along the anterior/posterior compartment boundary in third instar larval wing discs by Scer\GAL4ptc-559.1.