FlyBase Allele Report: Dmel\Ras85D[V12.cUa.UAS]

General Information

Symbol

Dmel\Ras85D^V12.cUa.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0276789

Feature type

allele

Associated gene

Dmel\Ras85D

Associated Insertion(s)

Carried in Construct

P{UAS-Ras85D.V12.U}

Also Known As

UAS-Ras^V12, UAS-ras^G12V, UAS-RasV12, Ras^V12, UAS-Ras85D^V12, UAS-Ras85D.V12

Key Links

Genomic Maps

JBrowse

Transgenic product class

missense_variant

(Jones et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Jones et al., 2012)

Mutagen

in vitro construct

(Jones et al., 2012)

Progenitor genotype

Carried in construct

P{UAS-Ras85D.V12.U}

Cytology

Description

UAS regulatory sequences drive expression of a V12 mutant of Ras85D.

(Jones et al., 2012)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Ras85D

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:9,512,257..9,512,257 [-]

Nucleotide change:

G9512257T

Amino acid change:

G12V | Ras85D-PA

Comment:

Analogous to oncogenic mutations in one of three human RAS genes; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(FlyBase curators, 2019-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cervical cancer

CEA

(Padash Barmchi et al., 2016)

CEA with Hsap\UBE3A^UAS.cRa, HPV18\E6^UAS.Tag:MYC

(Padash Barmchi et al., 2016)

CEA with Hsap\UBE3A^UAS.cRa, HPV18\E6^{V158A.UAS.Tag:MYC}

(Padash Barmchi et al., 2016)

model of cancer

CEA with l(2)gl⁴

(Fangninou et al., 2023, Liu et al., 2022, Yang et al., 2022)

CEA with Ptp61F^Δ

(Liu et al., 2022)

CEA with Syx7³¹¹⁹

(Liu et al., 2022)

CEA with Rabex-5³⁶⁷²

(Liu et al., 2022)

CEA with Vps36²⁵⁸⁶

(Liu et al., 2022)

CEA with TSG101^P26

(Liu et al., 2022)

CEA with N^DN.UAS.cUa

(Lee et al., 2021)

CEA with dlg1^RNAi.UAS.cUa

(Lodge et al., 2021)

CEA

(Yang et al., 2022, Dong et al., 2021, Yeom et al., 2021, Dunn et al., 2018, Vicente et al., 2018)

CEA with scrib¹

(Yang et al., 2022, Khezri et al., 2021)

CEA with baz⁴

(Yang et al., 2022)

CEA with fmt¹

(Yang et al., 2022)

CEA with dlg1^GD4689

(Yang et al., 2022)

CEA with Ptip³⁸⁰⁴

(Dong et al., 2021)

model of colorectal cancer

CEA

(Zipper et al., 2022)

CEA with Pten^sgRNA.UAS

(Zipper et al., 2022)

CEA with Med^sgRNA.UAS

(Zipper et al., 2022)

CEA with cic^sgRNA.UAS

(Zipper et al., 2022)

CEA with Apc2^sgRNA.UAS

(Zipper et al., 2022)

CEA with Apc^sgRNA.UAS

(Zipper et al., 2022)

CEA with p53^sgRNA.UAS

(Zipper et al., 2022)

CEA with p53^VDRC.cUa, Pten^GD13500, Apc^VDRC.cUa, Med^VDRC.cUa

(Bangi et al., 2016)

CEA with p53^VDRC.cUa, Pten^GD13500, Apc^VDRC.cUa

(Bangi et al., 2016)

CEA with p53^VDRC.cUa, Apc^VDRC.cUa, Med^VDRC.cUa

(Bangi et al., 2016)

CEA with Pten^GD13500, Apc^VDRC.cUa, Med^VDRC.cUa

(Bangi et al., 2016)

model of cardiomyopathy

CEA

(Yu et al., 2013)

model of adenocarcinoma

CEA with l(2)gl^GD4047

(Casas-Tintó et al., 2016)

CEA with l(2)gl^GD4047, wupA^JF02172

(Casas-Tintó et al., 2016)

model of carcinoma

CEA with Scer\GAL4^nub.PU

(Hogan et al., 2009)

CEA with l(2)gl⁴

(Sun et al., 2019)

CEA with dlg1^HMS00172

(Toggweiler et al., 2016)

model of intestinal cancer

CEA with Apc^Q8

(Campbell et al., 2019)

CEA

(Kim et al., 2022, Singh et al., 2016)

CEA with Apc2^N175K, Apc^Q8

(Parisi et al., 2023)

CEA with Apc^GD1333, p53^GD4483

(Quintero and Bangi, 2023)

CEA with Apc^GD1333, Pten^RNAi.UAS.cUa, p53^GD4483

(Quintero and Bangi, 2023)

CEA with Apc^GD1333, Med^GD1483, p53^GD4483

(Quintero and Bangi, 2023)

model of high grade glioma

CEA with Pten^{RNAi.Exel.UAS}

(Gangwani et al., 2020)

CEA

(Liu et al., 2021)

model of brain cancer

CEA with dlg1^GD4689

(Manzanero-Ortiz et al., 2021)

CEA with l(2)gl^KK100777

(Manzanero-Ortiz et al., 2021)

CEA with wts^KK101055

(Manzanero-Ortiz et al., 2021)

CEA with scrib⁶⁷³

(Manzanero-Ortiz et al., 2021)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of cancer

is exacerbated by ex^e1

(Liu et al., 2022)

is exacerbated by Ptp61F^Δ

(Liu et al., 2022)

is exacerbated by Not3^KK102144

(Vicente et al., 2018)

is exacerbated by M6^W186stop

(Dunn et al., 2018)

is ameliorated by Ptip³⁸⁰⁴

(Dong et al., 2021)

is exacerbated by p53^UAS.cUa

(Dong et al., 2021)

is ameliorated by Ilp8^MI00727

(Yeom et al., 2021)

model of intestinal cancer

is ameliorated by Cortactin^HMS00658

(Kim et al., 2022)

model of high grade glioma

is ameliorated by Dcp-1^RNAi.UAS.cUa

(Liu et al., 2021)

is exacerbated by Nmnat^UAS.PC

(Liu et al., 2021)

is ameliorated by Nmnat^RNAi.UAS.cUa

(Liu et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 2 )

This model includes alleles generated by the multi-gene construct P{UAS-Apc,Apc2,p53,Med,Pten,cic.sgRNA}, therefore all mutations in that construct are included in this model.

(Zipper et al., 2022)

The tumor invasion model is generated by expression of Ras85D^V12.cUa.UAS in combination with the l(2)gl⁴ mutation within eye disc clones.

(Sun et al., 2019)

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(FlyBase curators, 2019-)

This somatic variant has been found associated with cancer in each of the three paralogous genes in human (KRAS, HRAS, NRAS).

HRAS:p.Gly12Val

(FlyBase curators, 2019-)

Variants Synonym(s)

Associated human disease model(s)

cancer, multiple, RAS-related

External database links

ClinVar: 12600

Comments concerning this variant

KRAS:p.Gly12Val

(FlyBase curators, 2019-)

Variants Synonym(s)

Associated human disease model(s)

External database links

ClinVar: 12583

Comments concerning this variant

NRAS:p.Gly12Val

(FlyBase curators, 2019-)

Variants Synonym(s)

Associated human disease model(s)

cancer, multiple, RAS-related

External database links

ClinVar: 40470

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal cell migration | adult stage, with Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

abnormal size | adult stage, with Scer\GAL4^ey.PH

(Vicente et al., 2018)

abnormal size | somatic clone | wandering third instar larval stage, with Scer\GAL4^Act.PU

(Casas-Tintó et al., 2016)

abnormal sleep | adult stage, with Scer\GAL4^{Mef2.247.Switch}

(Machado Almeida et al., 2021)

decreased occurrence of cell division | adult stage, with Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

increased cell death | adult stage, with Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

increased cell number | adult stage, with Scer\GAL4^sev.PU

(Kim et al., 2004)

increased cell number | larval stage, with Scer\GAL4^NP5130

(Nirala et al., 2021)

increased cell size, with Scer\GAL4^tin.CΔ4

(Yu et al., 2013)

increased occurrence of cell division | adult stage, with Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

lethal - all die before end of larval stage, with Scer\GAL4^ap.PU

(Padash Barmchi et al., 2016)

lethal - all die before end of pupal stage, with Scer\GAL4^GMR.PU

(Padash Barmchi et al., 2016)

neoplasia | adult stage, with Scer\GAL4^ey.PH

(Vicente et al., 2018)

partially lethal, with Scer\GAL4^NP5130

(Nirala et al., 2021)

short lived, with Scer\GAL4^esg.PU

(Okada et al., 2023)

short lived | RU486 conditional, with Scer\GAL4^da.Switch.PT

(Slack et al., 2015)

some die during larval stage, with Scer\GAL4^nub.PU

(Okada et al., 2023)

visible | adult stage, with Scer\GAL4^ey.PH

(Vicente et al., 2018)

visible | adult stage, with Scer\GAL4^sev.PU

(Kim et al., 2004)

Phenotype Manifest In

adult heart, with Scer\GAL4^tin.CΔ4

(Yu et al., 2013)

adult heart muscle cell, with Scer\GAL4^tin.CΔ4

(Yu et al., 2013)

adult hindgut, with Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

adult pyloric epithelium, with Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

cardial cell, with Scer\GAL4^tin.CΔ4

(Yu et al., 2013)

embryonic/larval salivary gland | larval stage, with Scer\GAL4^NP5130

(Nirala et al., 2021)

eye, with Scer\GAL4^ey.PH

(Vicente et al., 2018)

eye, with Scer\GAL4^sev.PU

(Kim et al., 2004)

eye photoreceptor cell | adult stage | increased number, with Scer\GAL4^sev.PU

(Kim et al., 2004)

larval midgut epithelium | larval stage, with Scer\GAL4^NP5130

(Nirala et al., 2021)

myofilament, with Scer\GAL4^tin.CΔ4

(Yu et al., 2013)

ommatidium | adult stage, with Scer\GAL4^sev.PU

(Kim et al., 2004)

wing disc | somatic clone | wandering third instar larval stage, with Scer\GAL4^Act.PU

(Casas-Tintó et al., 2016)

wing disc | third instar larval stage, with Scer\GAL4^ap.PU

(Padash Barmchi et al., 2016)

Detailed Description

Statement

Reference

The expression of Ras85D^V12.cUa.UAS under the combined control of Scer\GAL4^NP5130 and Gal80[ts], induced for 18h during larval stage, results in increased the number of progenitors (Scer\GAL4^NP5130-positive ISCs/EBs) in the larval midgut. Larval salivary glands have an altered/twisted morphology.

(Nirala et al., 2021)

Whole-eye disc clones expressing Ras85D^V12.cUa.UAS alone under the control of Scer\GAL4^Act5C.PP do not form tumors.

(Sun et al., 2019)

The expression of Dl^UAS.cDa under the control of Scer\GAL4^ey.PH induces an increase in eye size, with a high frequency of tumors.

(Vicente et al., 2018)

The expression for one week during adulthood of Ras85D^V12.cUa.UAS under the combined control of Scer\GAL4^byn-Gal4 and Gal80[ts] (for the temporal control of expression) results in significant increases in apoptosis and senescence in the hindgut, in dissemination of hindgut cells to distant body areas, and in a severe increase in actively replicating cells (i.e. BrU-positive) in the pylorus, but does not affect the amount of food intake by adults, as compared to controls.

(Bangi et al., 2016)

Somatic clones expressing Ras85D^{V12.cUa.Scer\UAS} under the control of Scer\GAL4^Act.PU in wandering third instar wing discs present a significant increase in relative clonal area, as compared to control clones.

(Casas-Tintó et al., 2016)

The constitutive expression of Ras85D^{V12.cUa.Scer\UAS} under the control of Scer\GAL4^ap.PU leads to larval lethality and to the overgrowth, but not to the generation of mesenchymal-like cells, of third instar larval wing discs as compared to controls. The constitutive expression under the control of Scer\GAL4^GMR.PU leads to pupal lethality, but not to any cell migration defect in the pupal eye tissue, as compared to controls.

(Padash Barmchi et al., 2016)

Expression of Ras85D^{V12.cUa.Scer\UAS} under the control of Scer\GAL4^ptc.PU in cells of the wing disc proper has no significant effect on the morphology or proliferation of the overlying peripodial membrane cells in third instar larvae.

(Panneton et al., 2015)

trametinib treatment at 15.6uM doubles the lifespan of flies expressing Ras85D^{V12.cUa.Scer\UAS} under the control of Scer\GAL4^da.Switch.PT.

(Slack et al., 2015)

Adult Scer\GAL4^tin.CΔ4>Ras85D^{V12.cUa.Scer\UAS} flies have smaller heart chambers with reduced end-diastolic dimensions compared with controls. Histological analysis of cardiac chambers from adult transgenic flies show heart wall thicknesses that are two to three times compared with controls. Hearts isolated from the transgenic flies show abnormal cardiac morphology with myofiber disarray compared with controls. The number of cells in the transgenic hearts is similar to that in wild-type, indicating that the increased wall thickness is the result of cardiomyocyte hypertrophy, not an increase in cell proliferation.

(Yu et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ras85D^V12.cUa.UAS, Scer\GAL4^nub.PU has increased mortality during development phenotype, enhanceable by NetB^20xUAS.EGFP, Scer\GAL4^nub.PU

(Okada et al., 2023)

Ras85D^V12.cUa.UAS, Scer\GAL4^esg.PU has short lived phenotype, enhanceable by NetB^20xUAS.EGFP, Scer\GAL4^esg.PU

(Okada et al., 2023)

Ras85D^V12.cUa.UAS, Scer\GAL4^NP5130 has increased cell number | larval stage phenotype, enhanceable by Hinfp^GD9474, Scer\GAL4^NP5130

(Nirala et al., 2021)

Ras85D^V12.cUa.UAS, Scer\GAL4^NP5130 has increased mortality during development phenotype, enhanceable by Hinfp^GD9474, Scer\GAL4^NP5130

(Nirala et al., 2021)

Ras85D^V12.cUa.UAS, Scer\GAL4^ey.PH has visible | adult stage phenotype, enhanceable by Not3^KK102144, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Ras85D^V12.cUa.UAS, Scer\GAL4^ey.PH has neoplasia | adult stage phenotype, enhanceable by Not3^KK102144, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage phenotype, enhanceable by Med^VDRC.cUa/Apc^VDRC.cUa/p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage phenotype, enhanceable by Apc^VDRC.cUa/p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage phenotype, enhanceable by Med^VDRC.cUa/p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage phenotype, enhanceable by Med^VDRC.cUa/Apc^VDRC.cUa/p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage phenotype, enhanceable by Med^VDRC.cUa/Apc^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage phenotype, enhanceable by p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has increased occurrence of cell division | adult stage phenotype, enhanceable by Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage phenotype, enhanceable by Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has increased occurrence of cell division | adult stage phenotype, enhanceable by Apc^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage phenotype, enhanceable by Apc^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Apc^VDRC.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has increased occurrence of cell division | adult stage phenotype, enhanceable by Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has increased occurrence of cell division | adult stage phenotype, enhanceable by Apc^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage phenotype, enhanceable by Apc^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage phenotype, enhanceable by p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Apc^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has abnormal cell migration | adult stage phenotype, enhanceable by Tsc1^TRiP.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Apc^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has abnormal cell migration | adult stage phenotype, enhanceable by gig^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has hyperplasia | wandering third instar larval stage | somatic clone phenotype, enhanceable by wupA^JF02172, Scer\GAL4^Act.PU

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU has abnormal size | wandering third instar larval stage | somatic clone phenotype, enhanceable by wupA^f06492, Scer\GAL4^Act.PU

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has abnormal size | wandering third instar larval stage | somatic clone phenotype, enhanceable by wupA^f06492, Scer\GAL4^Act.PU

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU has increased cell number | adult stage phenotype, enhanceable by Mkp3^P3

(Kim et al., 2004)

Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU has visible | adult stage phenotype, enhanceable by Mkp3^P3

(Kim et al., 2004)

NOT Enhanced by

Statement

Reference

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has abnormal cell migration | adult stage phenotype, non-enhanceable by Apc^VDRC.cUa/p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Suppressed by

Statement

Reference

Ras85D^V12.cUa.UAS, Scer\GAL4^nub.PU has increased mortality during development phenotype, suppressible by NetB^VSH330183, Scer\GAL4^nub.PU

(Okada et al., 2023)

Ras85D^V12.cUa.UAS, Scer\GAL4^nub.PU has increased mortality during development phenotype, suppressible by NetB^KK103672, Scer\GAL4^nub.PU

(Okada et al., 2023)

Ras85D^V12.cUa.UAS, Scer\GAL4^esg.PU has short lived phenotype, suppressible | partially by NetB^KK103672, Scer\GAL4^esg.PU

(Okada et al., 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | adult stage | somatic clone - tissue specific phenotype, suppressible by Tk^JF01818, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | adult stage | somatic clone - tissue specific phenotype, suppressible by Tk^JF01818, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype, suppressible | partially by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype, suppressible by InR^GL00139, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype, suppressible | partially by InR^GL00139, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype, suppressible | partially by TkR99D^JF02663, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype, suppressible | partially by TkR99D^JF02663, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype, suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype, suppressible | partially by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | adult stage | somatic clone - tissue specific phenotype, suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has increased occurrence of cell division | third instar larval stage phenotype, suppressible | partially by Tep1^HMS00641, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has neoplasia | third instar larval stage phenotype, suppressible | partially by Tep1^HMS00641, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by Tep1^HMS00641, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has increased cell number | third instar larval stage phenotype, suppressible by Tep1^HMS00641, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has increased cell number | third instar larval stage phenotype, suppressible by yki^HMS00041, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has increased cell number | third instar larval stage phenotype, suppressible by yki^HMS00041/Tep1^HMS00641, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by yki^HMS00041, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has neoplasia | third instar larval stage phenotype, suppressible | partially by yki^HMS00041, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by yki^HMS00041/Tep1^HMS00641, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has neoplasia | third instar larval stage phenotype, suppressible | partially by yki^HMS00041/Tep1^HMS00641, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible by puc^UAS.cUa, Scer\GAL4^Act5C.PP

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has abnormal cell migration | somatic clone | larval stage phenotype, suppressible by puc^UAS.cUa, Scer\GAL4^Act5C.PP

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible | partially by lic^JF01433, Scer\GAL4^Act5C.PP

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has abnormal cell migration | somatic clone | larval stage phenotype, suppressible | partially by lic^JF01433, Scer\GAL4^Act5C.PP

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype, suppressible | partially by lic^G0252/lic[+]

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has abnormal cell migration | somatic clone | larval stage phenotype, suppressible | partially by lic^G0252/lic[+]

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has increased occurrence of cell division | adult stage phenotype, suppressible by p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has increased occurrence of cell division | adult stage phenotype, suppressible | partially by p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has increased cell death | adult stage phenotype, suppressible by Apc^VDRC.cUa/p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has decreased occurrence of cell division | adult stage phenotype, suppressible | partially by Apc^VDRC.cUa/p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has increased cell death | adult stage phenotype, suppressible by p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has decreased occurrence of cell division | adult stage phenotype, suppressible | partially by p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has increased cell death | adult stage phenotype, suppressible | partially by Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Apc^VDRC.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has increased cell death | adult stage phenotype, suppressible by p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has decreased occurrence of cell division | adult stage phenotype, suppressible | partially by Apc^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has abnormal size | somatic clone | wandering third instar larval stage phenotype, suppressible by wupA^JF02172, Scer\GAL4^Act.PU

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has hyperplasia | somatic clone | wandering third instar larval stage phenotype, suppressible by wupA^JF02172, Scer\GAL4^Act.PU

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has lethal - all die before end of P-stage | somatic clone phenotype, suppressible | partially by wupA^JF02172, Scer\GAL4^Act.PU

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU has increased cell number | adult stage phenotype, suppressible | partially by Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU has visible | adult stage phenotype, suppressible | partially by Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

NOT suppressed by

Statement

Reference

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | adult stage | somatic clone - tissue specific phenotype, non-suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | adult stage | somatic clone - tissue specific phenotype, non-suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | adult stage | somatic clone - tissue specific phenotype, non-suppressible by Tk^JF01818, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype, non-suppressible by InR^GL00139, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype, non-suppressible by InR^GL00139, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype, non-suppressible by InR^GL00139, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | somatic clone - tissue specific phenotype, non-suppressible by InR^GL00139, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype, non-suppressible by TkR99D^JF02663, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype, non-suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype, non-suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has increased cell death | adult stage phenotype, non-suppressible by Apc^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Apc^VDRC.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has increased cell death | adult stage phenotype, non-suppressible by p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has decreased occurrence of cell division | adult stage phenotype, non-suppressible by Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has decreased occurrence of cell division | adult stage phenotype, non-suppressible by Apc^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has decreased occurrence of cell division | adult stage phenotype, non-suppressible by p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^GMR.PU has lethal - all die before end of pupal stage phenotype, non-suppressible by Hsap\UBE3A^UAS.cRa/HPV18\E6^UAS.Tag:MYC, Scer\GAL4^GMR.PU

(Padash Barmchi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^da.Switch.PT has short lived | RU486 conditional phenotype, non-suppressible by chico¹/chico[+]

(Slack et al., 2015)

Enhancer of

Statement

Reference

Ras85D^V12.cUa.UAS, Scer\GAL4^Bx-MS1096 is an enhancer of increased size | larval stage phenotype of Nkap^GD11807, Scer\GAL4^Bx-MS1096

(Guo et al., 2024)

l(2)gl^GD4047/Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU is an enhancer of abnormal size | wandering third instar larval stage | somatic clone phenotype of Scer\GAL4^Act.PU, wupA^f06492

(Casas-Tintó et al., 2016)

NOT Enhancer of

Statement

Reference

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU is a non-enhancer of abnormal size | wandering third instar larval stage | somatic clone phenotype of Scer\GAL4^Act.PU, wupA^f06492

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Asam\aopP^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Jones et al., 2012)

Suppressor of

Statement

Reference

Scer\GAL4^spok.1.45/Ras85D^V12.cUa.UAS is a suppressor of abnormal developmental rate phenotype of Kdm5¹⁴⁰

(Drelon et al., 2019)

Scer\GAL4^spok.1.45/Ras85D^V12.cUa.UAS is a suppressor of increased mortality during development phenotype of Kdm5¹⁴⁰

(Drelon et al., 2019)

Ras85D^V12.cUa.UAS/Scer\GAL4^da.Switch.PT is a suppressor of long lived | dominant phenotype of chico¹

(Slack et al., 2015)

Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU is a suppressor | partially of decreased cell number | adult stage phenotype of Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

NOT Suppressor of

Statement

Reference

Ras85D^V12.cUa.UAS, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Asam\aopP^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Jones et al., 2012)

Other

Statement

Reference

Nkap^UAS.cGa, Ras85D^V12.cUa.UAS, Scer\GAL4^Bx-MS1096 has increased size | larval stage phenotype

(Guo et al., 2024)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has short lived | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased occurrence of cell division | cell non-autonomous | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased occurrence of cell division | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has short lived | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell size | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased occurrence of cell division | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has short lived | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has increased cell growth rate | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has abnormal cell number | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Hinfp^GD9474, Ras85D^V12.cUa.UAS, Scer\GAL4^NP5130 has partially lethal - majority die phenotype

(Nirala et al., 2021)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has abnormal neuroanatomy | third instar larval stage phenotype

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has increased cell number | third instar larval stage phenotype

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has neoplasia | third instar larval stage phenotype

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has increased occurrence of cell division | third instar larval stage phenotype

(Gangwani et al., 2020)

Kdm5¹⁴⁰, Ras85D^V12.cUa.UAS, Scer\GAL4^spok.1.45 has visible | adult stage phenotype

(Drelon et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has neoplasia | somatic clone | larval stage phenotype

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has abnormal cell migration | somatic clone | larval stage phenotype

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, lic^UAS.ORF has neoplasia | somatic clone | larval stage phenotype

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, lic^UAS.ORF has abnormal cell migration | somatic clone | larval stage phenotype

(Sun et al., 2019)

Hsap\MAP2K3^UAS.cSa, Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP has neoplasia | somatic clone | larval stage phenotype

(Sun et al., 2019)

Hsap\MAP2K3^UAS.cSa, Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP has abnormal cell migration | somatic clone | larval stage phenotype

(Sun et al., 2019)

Apc^VDRC.cUa, Med^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has short lived phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Med^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has hyperplasia | adult stage phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Med^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has neoplasia phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Med^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has abnormal cell shape | adult stage phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has hyperplasia | adult stage phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has neoplasia phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has abnormal cell shape | adult stage phenotype

(Bangi et al., 2016)

Med^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has hyperplasia | adult stage phenotype

(Bangi et al., 2016)

Med^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has abnormal cell shape | adult stage phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Med^VDRC.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has hyperplasia | adult stage phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Med^VDRC.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has neoplasia phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Med^VDRC.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has abnormal cell shape | adult stage phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Med^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has short lived phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Med^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has hyperplasia | adult stage phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Med^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has neoplasia phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Med^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has abnormal cell shape | adult stage phenotype

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has hyperplasia | somatic clone | wandering third instar larval stage phenotype

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047, wupA^JF02172 has short lived phenotype

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, wupA^f06492 has neoplasia | somatic clone | wandering third instar larval stage phenotype

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047, wupA^f06492 has lethal - all die before end of P-stage | somatic clone phenotype

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, wupA^f06492 has abnormal size | somatic clone | wandering third instar larval stage phenotype

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has lethal - all die before end of P-stage | somatic clone phenotype

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has abnormal size | somatic clone | wandering third instar larval stage phenotype

(Casas-Tintó et al., 2016)

HPV18\E6^UAS.Tag:MYC, Hsap\UBE3A^UAS.cRa, Ras85D^V12.cUa.UAS, Scer\GAL4^ap.PU has abnormal cell shape | third instar larval stage phenotype

(Padash Barmchi et al., 2016)

HPV18\E6^UAS.Tag:MYC, Hsap\UBE3A^UAS.cRa, Ras85D^V12.cUa.UAS, Scer\GAL4^ap.PU has abnormal cell adhesion | third instar larval stage phenotype

(Padash Barmchi et al., 2016)

HPV18\E6^UAS.Tag:MYC, Hsap\UBE3A^UAS.cRa, Ras85D^V12.cUa.UAS, Scer\GAL4^GMR.PU has abnormal cell migration | pupal stage phenotype

(Padash Barmchi et al., 2016)

HPV18\E6^{V158A.UAS.Tag:MYC}, Hsap\UBE3A^UAS.cRa, Ras85D^V12.cUa.UAS, Scer\GAL4^GMR.PU has abnormal cell migration | pupal stage phenotype

(Padash Barmchi et al., 2016)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ras85D^V12.cUa.UAS, Scer\GAL4^NP5130 has larval midgut epithelium | larval stage phenotype, enhanceable by Hinfp^GD9474, Scer\GAL4^NP5130

(Nirala et al., 2021)

Ras85D^V12.cUa.UAS, Scer\GAL4^NP5130 has embryonic/larval salivary gland | larval stage phenotype, enhanceable by Hinfp^GD9474, Scer\GAL4^NP5130

(Nirala et al., 2021)

Ras85D^V12.cUa.UAS, Scer\GAL4^ey.PH has eye phenotype, enhanceable by Not3^KK102144, Scer\GAL4^ey.PH

(Vicente et al., 2018)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, enhanceable by Med^VDRC.cUa/Apc^VDRC.cUa/p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium phenotype, enhanceable by Med^VDRC.cUa/Apc^VDRC.cUa/p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, enhanceable by Apc^VDRC.cUa/p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium phenotype, enhanceable by Apc^VDRC.cUa/p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, enhanceable by Med^VDRC.cUa/p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium phenotype, enhanceable by Med^VDRC.cUa/p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, enhanceable by Med^VDRC.cUa/Apc^VDRC.cUa/p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium phenotype, enhanceable by Med^VDRC.cUa/Apc^VDRC.cUa/p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, enhanceable by Med^VDRC.cUa/Apc^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium phenotype, enhanceable by Med^VDRC.cUa/Apc^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, enhanceable by p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium phenotype, enhanceable by p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, enhanceable by Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium phenotype, enhanceable by Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult pyloric epithelium phenotype, enhanceable by Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, enhanceable by Apc^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium phenotype, enhanceable by Apc^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult pyloric epithelium phenotype, enhanceable by Apc^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, enhanceable by Apc^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium phenotype, enhanceable by Apc^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Apc^VDRC.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult pyloric epithelium phenotype, enhanceable by Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult pyloric epithelium phenotype, enhanceable by Apc^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, enhanceable by p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium phenotype, enhanceable by p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Apc^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has adult hindgut epithelium phenotype, enhanceable by Tsc1^TRiP.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Apc^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has adult hindgut epithelium phenotype, enhanceable by gig^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has fat body | wandering third instar larval stage | somatic clone phenotype, enhanceable by wupA^JF02172, Scer\GAL4^Act.PU

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU has wing disc | wandering third instar larval stage | somatic clone phenotype, enhanceable by wupA^f06492, Scer\GAL4^Act.PU

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has wing disc | wandering third instar larval stage | somatic clone phenotype, enhanceable by wupA^f06492, Scer\GAL4^Act.PU

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU has eye photoreceptor cell | adult stage | increased number phenotype, enhanceable by Mkp3^P3

(Kim et al., 2004)

Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU has ommatidium | adult stage phenotype, enhanceable by Mkp3^P3

(Kim et al., 2004)

Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU has eye phenotype, enhanceable by Mkp3^P3

(Kim et al., 2004)

NOT Enhanced by

Statement

Reference

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut phenotype, non-enhanceable by Apc^VDRC.cUa/p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium phenotype, non-enhanceable by Apc^VDRC.cUa/p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Suppressed by

Statement

Reference

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enteroendocrine cell | increased number | somatic clone - tissue specific phenotype, suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enteroendocrine cell | increased number | somatic clone - tissue specific phenotype, suppressible | partially by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has intestinal stem cell | increased number | cell non-autonomous | adult stage | somatic clone - tissue specific phenotype, suppressible | partially by Tk^JF01818, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has intestinal stem cell | increased number | cell non-autonomous | adult stage | somatic clone - tissue specific phenotype, suppressible | partially by TkR99D^JF02663, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has larval central brain | third instar larval stage phenotype, suppressible | partially by Tep1^HMS00641, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has neuroblast | increased number | third instar larval stage phenotype, suppressible by Tep1^HMS00641, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has neuroblast | increased number | third instar larval stage phenotype, suppressible by yki^HMS00041, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has neuroblast | increased number | third instar larval stage phenotype, suppressible by yki^HMS00041/Tep1^HMS00641, Scer\GAL4^repo.PU

(Gangwani et al., 2020)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has larval ventral nerve cord | somatic clone | larval stage phenotype, suppressible by puc^UAS.cUa, Scer\GAL4^Act5C.PP

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has eye disc | somatic clone phenotype, suppressible by puc^UAS.cUa, Scer\GAL4^Act5C.PP

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has larval ventral nerve cord | somatic clone | larval stage phenotype, suppressible | partially by lic^JF01433, Scer\GAL4^Act5C.PP

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has eye disc | somatic clone phenotype, suppressible | partially by lic^JF01433, Scer\GAL4^Act5C.PP

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has larval ventral nerve cord | somatic clone | larval stage phenotype, suppressible | partially by lic^G0252/lic[+]

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has eye disc | somatic clone phenotype, suppressible | partially by lic^G0252/lic[+]

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult pyloric epithelium phenotype, suppressible by p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium phenotype, suppressible | partially by p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium | adult stage phenotype, suppressible | partially by Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium | adult stage phenotype, suppressible | partially by p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium | adult stage phenotype, suppressible | partially by Apc^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Apc^VDRC.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium | adult stage phenotype, suppressible by p53^VDRC.cUa/Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has wing disc | somatic clone | wandering third instar larval stage phenotype, suppressible by wupA^JF02172, Scer\GAL4^Act.PU

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has eye disc | somatic clone | wandering third instar larval stage phenotype, suppressible by wupA^JF02172, Scer\GAL4^Act.PU

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU has eye photoreceptor cell | increased number | adult stage phenotype, suppressible | partially by Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU has ommatidium | adult stage phenotype, suppressible | partially by Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU has eye phenotype, suppressible | partially by Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

NOT suppressed by

Statement

Reference

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enteroendocrine cell | increased number | somatic clone - tissue specific phenotype, non-suppressible by sc^JF02104, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has intestinal stem cell | increased number | cell non-autonomous | adult stage | somatic clone - tissue specific phenotype, non-suppressible by Pten^RNAi.UAS.cUa, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has intestinal stem cell | increased number | cell non-autonomous | adult stage | somatic clone - tissue specific phenotype, non-suppressible by InR^GL00139, Scer\GAL4^{Act5C.PS-FRT3}

(Quintero and Bangi, 2023)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium | adult stage phenotype, non-suppressible | partially by Apc^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Apc^VDRC.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium | adult stage phenotype, non-suppressible by p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium | adult stage phenotype, non-suppressible by Apc^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium | adult stage phenotype, non-suppressible by p53^VDRC.cUa, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult hindgut epithelium | adult stage phenotype, non-suppressible | partially by Pten^GD13500, Scer\GAL4^byn-Gal4

(Bangi et al., 2016)

Enhancer of

Statement

Reference

Ras85D^V12.cUa.UAS, Scer\GAL4^Bx-MS1096 is an enhancer of wing disc | larval stage phenotype of Nkap^GD11807, Scer\GAL4^Bx-MS1096

(Guo et al., 2024)

l(2)gl^GD4047/Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU is an enhancer of wing disc | wandering third instar larval stage | somatic clone phenotype of Scer\GAL4^Act.PU, wupA^f06492

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^ptc-559.1 is an enhancer of wing disc phenotype of Scer\GAL4^ptc-559.1, Vha44^UAS.Tag:HA

(Petzoldt et al., 2013)

Ras85D^V12.cUa.UAS, Scer\GAL4^nub.PU is an enhancer of wing pouch phenotype of Scer\GAL4^nub.PU, Vha44^UAS.Tag:HA

(Petzoldt et al., 2013)

NOT Enhancer of

Statement

Reference

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU is a non-enhancer of wing disc | wandering third instar larval stage | somatic clone phenotype of Scer\GAL4^Act.PU, wupA^f06492

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Asam\aopP^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Jones et al., 2012)

Suppressor of

Statement

Reference

Ras85D^V12.cUa.UAS, Scer\GAL4^sev.PU is a suppressor | partially of eye photoreceptor cell | adult stage | decreased number phenotype of Mkp3^UAS.cKa, Scer\GAL4^sev.PU

(Kim et al., 2004)

NOT Suppressor of

Statement

Reference

Ras85D^V12.cUa.UAS, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Asam\aopP^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Jones et al., 2012)

Other

Statement

Reference

Nkap^UAS.cGa, Ras85D^V12.cUa.UAS, Scer\GAL4^Bx-MS1096 has wing disc | larval stage phenotype

(Guo et al., 2024)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has intestinal stem cell | increased number | cell non-autonomous | adult stage | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enteroendocrine cell | increased number | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enterocyte | increased number | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enteroendocrine cell | increased number | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Pten^RNAi.UAS.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enterocyte | increased number | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Apc^GD1333, Med^GD1483, Ras85D^V12.cUa.UAS, Scer\GAL4^{Act5C.PS-FRT3}, p53^GD4483 has adult enteroendocrine cell | increased number | somatic clone - tissue specific phenotype

(Quintero and Bangi, 2023)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has larval central brain | third instar larval stage phenotype

(Gangwani et al., 2020)

Pten^{RNAi.Exel.UAS}, Ras85D^V12.cUa.UAS, Scer\GAL4^repo.PU has neuroblast | increased number | third instar larval stage phenotype

(Gangwani et al., 2020)

Kdm5¹⁴⁰, Ras85D^V12.cUa.UAS, Scer\GAL4^spok.1.45 has wing phenotype

(Drelon et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has eye disc | somatic clone phenotype

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, l(2)gl⁴ has larval ventral nerve cord | somatic clone | larval stage phenotype

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, lic^UAS.ORF has eye disc | somatic clone phenotype

(Sun et al., 2019)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP, lic^UAS.ORF has larval ventral nerve cord | somatic clone | larval stage phenotype

(Sun et al., 2019)

Hsap\MAP2K3^UAS.cSa, Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP has eye disc | somatic clone phenotype

(Sun et al., 2019)

Hsap\MAP2K3^UAS.cSa, Ras85D^V12.cUa.UAS, Scer\GAL4^Act5C.PP has larval ventral nerve cord | somatic clone | larval stage phenotype

(Sun et al., 2019)

Apc^VDRC.cUa, Med^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has adult pylorus phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has adult pylorus phenotype

(Bangi et al., 2016)

Med^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has adult pylorus phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Med^VDRC.cUa, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4, p53^VDRC.cUa has adult pylorus phenotype

(Bangi et al., 2016)

Apc^VDRC.cUa, Med^VDRC.cUa, Pten^GD13500, Ras85D^V12.cUa.UAS, Scer\GAL4^byn-Gal4 has adult pylorus phenotype

(Bangi et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has fat body | somatic clone | wandering third instar larval stage phenotype

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, wupA^f06492 has wing disc | somatic clone | wandering third instar larval stage phenotype

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has wing disc | somatic clone | wandering third instar larval stage phenotype

(Casas-Tintó et al., 2016)

Ras85D^V12.cUa.UAS, Scer\GAL4^Act.PU, l(2)gl^GD4047 has eye disc | somatic clone | wandering third instar larval stage phenotype

(Casas-Tintó et al., 2016)

HPV18\E6^UAS.Tag:MYC, Hsap\UBE3A^UAS.cRa, Ras85D^V12.cUa.UAS, Scer\GAL4^ap.PU has imaginal disc epithelial cell | pupal stage phenotype

(Padash Barmchi et al., 2016)

HPV18\E6^{V158A.UAS.Tag:MYC}, Hsap\UBE3A^UAS.cRa, Ras85D^V12.cUa.UAS, Scer\GAL4^ap.PU has imaginal disc epithelial cell | pupal stage phenotype

(Padash Barmchi et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expressing Pten^{dsRNA.Exel.UAS} and Ras85D^V12.cUa.UAS under the control of Scer\GAL4^repo.PU induces larval central brain gliomas; brain lobes are enlarged; there is an increase in mitosis; there is an increase in the number of neuroblasts; neuroblasts and ganglion mother cells seem to undergo a lateral shift at the edge of the central brain abutting the optic lobe.

(Gangwani et al., 2020)

Expression of Ras85D^V12.cUa.UAS under the control of Scer\GAL4^spok.1.45 in the Kdm5¹⁴⁰ homozygous background leads to curved-down wings compared to controls.

(Drelon et al., 2019)

Whole-eye disc clones both l(2)gl⁴ homozygous and expressing Ras85D^V12.cUa.UAS under the control of Scer\GAL4^Act5C.PP form tumors that invade into the VNC; the VNC invasion phenotype is nearly suppressed by the co-expression of puc^UAS.cUa, partially suppressed by the co-expression of lic^JF01433 and partially suppressed by lic^G0252 heterozygosity; however, the size of the primary tumor is not affected by these manipulations.

Likewise, whole-eye disc clones co-expressing Ras85D^V12.cUa.UAS and lic^UAS.ORF under the control of Scer\GAL4^Act5C.PP frequently form tumors that invade into the VNC.

(Sun et al., 2019)

Quadruple or quintuple co-expression for one week during adulthood of Ras85D^V12.cUa.UAS, p53^VDRC.cUa, Pten^GD13500, Apc^VDRC.cUa and/or Med^VDRC.cUa under the combined control of Scer\GAL4^byn-Gal4, Dicer-2 (for efficient RNAi) and Gal80[ts] (for the temporal control of expression) leads to multilayered epithelia that form bulges at discrete points along the hindgut (only in animals that contained Ras85D^V12.cUa.UAS and Apc^VDRC.cUa together) and to an expanded pylorus (observed in the quintuple and all quadruple conditions that carried Ras85D^V12.cUa.UAS); the quadruple co-expression conditions Ras85D^V12.cUa.UAS+p53^VDRC.cUa+Pten^GD13500+Med^VDRC.cUa and p53^VDRC.cUa+Pten^GD13500+Apc^VDRC.cUa+Med^VDRC.cUa do not lead to multilayering.

All quadruple and quintuple co-expression conditions - with the exception of the quadruple p53^VDRC.cUa+Pten^GD13500+Med^VDRC.cUa+Apc^VDRC.cUa - result in numerous hindgut cells losing their characteristic epithelial shape to assume a more mesenchymal appearance (processes extending towards the basement membrane and surrounding muscle layer), migrate locally and disseminate to distant sites in the organism (e.g. head, legs, fat body, ovaries, below the epidermis of the abdomen and within the abdominal cavity). Similar hindgut cell dissemination is observed upon the triple expressions of Ras85D^V12.cUa.UAS+p53^VDRC.cUa+Pten^GD13500, Ras85D^V12.cUa.UAS+Apc^VDRC.cUa+Pten^GD13500 or Ras85D^V12.cUa.UAS+p53^VDRC.cUa+Apc^VDRC.cUa, the double expressions of Ras85D^V12.cUa.UAS+p53^VDRC.cUa, Ras85D^V12.cUa.UAS+Pten^GD13500 or Ras85D^V12.cUa.UAS+Apc^VDRC.cUa, all of which are more severe than upon the single expression of Ras85D^V12.cUa.UAS alone.

(Bangi et al., 2016)

Somatic clones co-expressing wupA^f06492 and Ras85D^{V12.cUa.Scer\UAS} under the control of Scer\GAL4^Act.PU in wandering third instar larval wing discs present a significant increase in the relative clonal area as compared to clones only expressing Ras85D^{V12.cUa.Scer\UAS}, but not to clones only expressing wupA^f06492, and lead to overgrowths protruding from the wing disc in almost half of cases.

The induction of somatic clones co-expressing l(2)gl^GD4047 and Ras85D^{V12.cUa.Scer\UAS} under the control of Scer\GAL4^Act.PU during second instar larval stage results in the accumulation of clonal cells in the wandering third instar larval fat body, which is enhanced by the additional co-expression of wupA^JF02172; the induction of these clones also results in lethality before adulthood, which is partially rescued by the additional co-expression of wupA^JF02172, although the surviving adults display a shorter life-span as compared to wild-type controls.

In wandering third instar larvae, somatic clones co-expressing l(2)gl^GD4047 and Ras85D^{V12.cUa.Scer\UAS} under the control of Scer\GAL4^Act.PU in both eye discs and wing discs exhibit a significant increase in the relative clonal area and hyperplasia as compared to control clones; wing disc clone cells localize both basally and apically in the disc. All of these phenotypes are suppressed by the additional co-expression of wupA^JF02172, even leading to a significant decrease in the wing disc clonal area as compared to control clones.

Somatic clones co-expressing l(2)gl^GD4047, Ras85D^{V12.cUa.Scer\UAS} and wupA^f06492 under the control of Scer\GAL4^Act.PU in wandering third instar larvae wing discs exhibit a significant increase in relative clonal area as compared to clones only co-expressing l(2)gl^GD4047 and Ras85D^{V12.cUa.Scer\UAS} or only expressing wupA^f06492; animals bearing clones co-expressing l(2)gl^GD4047, Ras85D^{V12.cUa.Scer\UAS} and wupA^f06492 do not reach adulthood.

(Casas-Tintó et al., 2016)

Co-expression of Ras85D^{V12.cUa.Scer\UAS} increases the extent of migration into the posterior compartment of anterior cells expressing Vha44^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ptc-559.1 in the wing disc.

Co-expression of Ras85D^{V12.cUa.Scer\UAS} enhances the wing pouch overgrowth caused by expression of Vha44^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^nub.PU.

(Petzoldt et al., 2013)

Xenogenetic Interactions

Statement

Reference

Whole-eye disc clones co-expressing Ras85D^V12.cUa.UAS and Hsap\MAP2K3^UAS.cSa under the control of Scer\GAL4^Act5C.PP frequently form tumors that invade into the VNC.

(Sun et al., 2019)

The triple co-expression of Ras85D^{V12.cUa.Scer\UAS}, Hsap\UBE3A^Scer\UAS.cRa and either HPV18\E6^{Scer\UAS.T:Hsap\MYC} or HPV18\E6^{V158A.Scer\UAS.T:Hsap\MYC}, under the control of Scer\GAL4^GMR.PU, leads to the migration of a considerable proportion of expressing eye tissue cells into distant pupal tissues (e.g. abdomen), as compared to controls. The triple co-expression of Ras85D^{V12.cUa.Scer\UAS}, Hsap\UBE3A^Scer\UAS.cRa and HPV18\E6^{V158A.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PU does not suppress the pupal lethality induced by the single expression of Ras85D^{V12.cUa.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

(Padash Barmchi et al., 2016)

Co-expression of Ras85D^{V12.cUa.Scer\UAS} with Zzzz\aopP^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GMR.PF does not alter the eye morphology of Zzzz\aopP^{Scer\UAS.T:Hsap\MYC}-expressing eyes.

(Jones et al., 2012)

Complementation and Rescue Data

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Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ras85D^{V12.cUa.Scer\UAS}

Ras85D^V12.cUa.UAS

Ras^V12

(Petzoldt et al., 2013)

Ras^v12

(Yeom et al., 2021, Shu et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (58)

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