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General Information
Symbol
Dmel\rlSem.cUa.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0276790
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-rlSEM, UAS-Erksem, UAS-Sem, rlSEM, UAS-rl(sem)
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of rl(sem).

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies with expression of rlSem.cUa.UAS driven by Scer\GAL4GMR.PU have a rough eye phenotype, with a significant increase in the number of R cells per ommatidium.

Expression of rlSem.cUa.UAS under the control of Scer\GAL4btl.PS results in a branching extension delay in 27% of embryonic dorsal branches and incomplete or impaired cell intercalation.

Expression of rlSem.cUa.UAS under the control of Scer\GAL4Bx-MS1096 results in ectopic wing veins.

The expression of rlSem.cUa.UAS under the control of Scer\GAL4Bx-MS1096 leads to the formation of extra wing vein material.

Expression of rlSem.cUa.UAS under the control of Scer\GAL4bs-1348 induces differentiation of ectopic wing vein tissue.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
Suppressed by
NOT suppressed by
Statement
Reference
NOT Enhancer of
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Suppressed by
NOT suppressed by
Enhancer of
NOT Enhancer of
Suppressor of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Expression of tayEP-866 partially suppresses the ectopic wing vein phenotype seen when rlSem.cUa.UAS is expressed under the control of Scer\GAL4salm.EPv.

Co-expression of DJ-1αUAS.cMa or dj-1βUAS.cMa or presence of dj-1βΔ93/+ does not alter eye phenotypes in flies with expression of rlSem.cUa.UAS driven by Scer\GAL4GMR.PU.

The formation of ectopic wing veins in flies expressing rlSem.cUa.UAS under the control of Scer\GAL4salm-459.2 is weakly enhanced in a osa308/+ mutant background, but strongly enhanced by over-expression of osaUAS.cCa.

Coexpression of rlSem.cUa.UAS suppresses the tracheal branching defects of Scer\GAL4btl.PS>Mkp3GS801 embryos.

Coexpression of rlSem.cUa.UAS and E(spl)mβ-HLHUAS.cdCa, under the control of Scer\GAL4Bx-MS1096, results in wing vein thickening that is indistinguishable from expression of rlSem.cUa.UAS alone. Likewise, coexpression of groUAS.cAa with rlSem.cUa.UAS, under the control of Scer\GAL4Bx-MS1096, is unable to suppress the thick wing vein phenotype. Coexpression of rlSem.cUa.UAS and groAA.UAS, under the control of Scer\GAL4Bx-MS1096, results in wings with little vein material, similar to the phenotype when only groAA.UAS is expressed.

Expression of rlSem.cUa.UAS under the control of Scer\GAL4dpp.3KK suppresses the loss of wing vein phenotype of Scer\GAL4dpp.3KK>Mkp3EP-M76 flies.

Ectopic eyes in eyaUAS.cHa; Scer\GAL4dpp.blk1; rlSem.cUa.UAS are generally larger, and have more ommatidial definition than those in eyaUAS.cHa; Scer\GAL4dpp.blk1 flies. The proportion of eyaUAS.cHa; Scer\GAL4dpp.PH flies with blistered wings (76%) is increased by heterozygosity for rlSem.cUa.UAS to 93%, while the proportion with only mild wing defects is decreased from 24% to 7%. (All data from experiments with a single, 'strong' P{UAS-eya.H} insertion; n=approximately 300 in each case).

Xenogenetic Interactions
Statement
Reference

The additional co-expression of rlSem.cUa.UAS does not modify the fully penetrant rough eye phenotype resulting from the co-expression of HPV18\E6UAS.Tag:MYC and Hsap\UBE3AUAS.cRa under the control of Scer\GAL4GMR.PU.

Co-expression of rlsem.cUa.Scer\UAS with Zzzz\aopPScer\UAS.T:Hsap\MYC under the control of Scer\GAL4GMR.PF does not alter the eye morphology of Zzzz\aopPScer\UAS.T:Hsap\MYC-expressing eyes.

Co-expression of rlsem.cUa.Scer\UAS with Zzzz\VopAScer\UAS.cJa under the control of Scer\GAL4GMR.PF completely suppresses the rough eye phenotype resulting from the expression of Zzzz\VopAScer\UAS.cJa.

Expression of rlsem.cUa.Scer\UAS suppresses the rough eye phenotype seen when Zzzz\VopAScer\UAS.T:Hsap\MYC is expressed under the control of Scer\GAL4GMR.PF.

Expression of Bant\lefUAS.cGa does not suppress the ectopic vein phenotype of rlSem.cUa.UAS under the control of Scer\GAL4Bx-MS1096.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
rlSem.cUa.Scer\UAS
rlSem.cUa.UAS
rlsem.cUa.Scer\UAS
Name Synonyms
Secondary FlyBase IDs
    References (25)