Allele Dmel\Uba2^N2

General Information
Symbol	Dmel\Uba2^N2	Species	D. melanogaster
Name		FlyBase ID	FBal0276845
Feature type	allele	Associated gene	Dmel\Uba2

Allele class	amorphic allele - molecular evidence
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	amorphic allele - molecular evidence (Kanakousaki and Gibson, 2012)
Mutagen	P-element activity (Kanakousaki and Gibson, 2012)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{EP}G4672 (Kanakousaki and Gibson, 2012)
Nature of the lesion	Statement Reference Incomplete excision of the progenitor insertion, resulting in an internal deletion of the inserted element, without disrupting Uba2 genomic sequences. (Kanakousaki and Gibson, 2012)
Caused by insertion	P{EP-ΔN2}Uba2^N2 (Kanakousaki and Gibson, 2012)
Cytology
Phenotypic Data
Phenotypic Class
	cell lethal \| somatic clone \| third instar larval stage (Kanakousaki and Gibson, 2012) decreased cell number \| somatic clone \| third instar larval stage (Kanakousaki and Gibson, 2012) increased cell death \| somatic clone \| third instar larval stage (Kanakousaki and Gibson, 2012) lethal (with Df(3L)Exel6112) (Kanakousaki and Gibson, 2012) lethal \| P-stage \| recessive (Kanakousaki and Gibson, 2012)
Phenotype Manifest In
	imaginal disc (Kanakousaki and Gibson, 2012) optic lobe (Kanakousaki and Gibson, 2012) wing disc \| somatic clone (Kanakousaki and Gibson, 2012)
Detailed Description
	Statement Reference Homozygotes show early pupal lethality, have missing imaginal discs and severely reduced optic lobes. Homozygous clones in the wing imaginal disc show reduced growth and high levels of cell death. (Kanakousaki and Gibson, 2012)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Df(3L)Exel6112/Uba2^N2 is rescued by Uba2^+t4.4 (Kanakousaki and Gibson, 2012) Uba2^N2 is rescued by Scer\GAL4^Act.PU/Uba2^Scer\UAS.cKa (Kanakousaki and Gibson, 2012)
Comments	Expression of Uba2[Scer\UAS.cKa] under the control of Scer\GAL4[Act.PU] in the clone rescues the reduced growth and cell death seen in Uba2[N2] clones. (Kanakousaki and Gibson, 2012)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Uba2^N2 uba2^N2 (Kanakousaki and Gibson, 2012)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Kanakousaki and Gibson, 2012, Development 139(15): 2751--2762 A differential requirement for SUMOylation in proliferating and non-proliferating cells during Drosophila development. [FBrf0218825]

Allele Dmel\Uba2N2

Allele Dmel\Uba2^N2